Immunohistochemical detection of mutated epidermal growth factor receptors in pulmonary adenocarcinoma
H Nakamura, A Mochizuki, T Shinmyo… - Anticancer …, 2010 - ar.iiarjournals.org
Background: Epidermal growth factor receptor (EGFR) mutational analysis has become
essential in determining a therapeutic strategy for lung cancer. This study validated the …
essential in determining a therapeutic strategy for lung cancer. This study validated the …
[HTML][HTML] Immunohistochemical detection of mutations in the epidermal growth factor receptor gene in lung adenocarcinomas using mutation-specific antibodies
Y Xiong, Y Bai, N Leong, TS Laughlin, PG Rothberg… - Diagnostic …, 2013 - Springer
Background The recent development of antibodies specific for the major hotspot mutations
in the epidermal growth factor receptor (EGFR), L858R and E746_A750del, may provide an …
in the epidermal growth factor receptor (EGFR), L858R and E746_A750del, may provide an …
Immunostaining with EGFR mutation–specific antibodies: a reliable screening method for lung adenocarcinomas harboring EGFR mutation in biopsy and resection …
X Fan, B Liu, H Xu, B Yu, S Shi, J Zhang, X Wang… - Human pathology, 2013 - Elsevier
Mutation analysis of epidermal growth factor receptor (EGFR) is essential in determining the
therapeutic strategy for lung adenocarcinoma. Immunohistochemical (IHC) staining with …
therapeutic strategy for lung adenocarcinoma. Immunohistochemical (IHC) staining with …
[HTML][HTML] Detection of epidermal growth factor receptor mutations in lung adenocarcinoma cytological specimens by immunocytochemistry
M Yoshida, T Nagatomo, T Ohnishi… - Molecular and …, 2017 - spandidos-publications.com
Tyrosine kinase inhibitors of epidermal growth factor receptor (EGFR) improve the survival of
patients with lung adenocarcinoma, and determine the EGFR mutation status before …
patients with lung adenocarcinoma, and determine the EGFR mutation status before …
EGFR mutations in lung adenocarcinomas: clinical testing experience and relationship to EGFR gene copy number and immunohistochemical expression
Lung adenocarcinomas responsive to epidermal growth factor receptor (EGFR) tyrosine
kinase inhibitors possess EGFR mutations and often increased EGFR copy number. We …
kinase inhibitors possess EGFR mutations and often increased EGFR copy number. We …
Epidermal growth factor receptor (EGFR) high gene copy number and activating mutations in lung adenocarcinomas are not consistently accompanied by positivity for …
F Pinter, J Papay, A Almasi, Z Sapi, E Szabo… - The Journal of Molecular …, 2008 - Elsevier
The purpose of this study was to investigate whether detectable protein biomarker
overexpression is a prerequisite for the presence of increased gene copy number or …
overexpression is a prerequisite for the presence of increased gene copy number or …
Two allele-specific PCR assays for screening epidermal growth factor receptor gene hotspot mutations in lung adenocarcinoma
R Dahse, A Berndt, AK Dahse… - Molecular Medicine …, 2008 - spandidos-publications.com
In patients with non-small cell lung cancer, mutations in the EGFR tyrosine kinase domain
have been associated with improved response to tyrosine kinase inhibitors such as gefitinib …
have been associated with improved response to tyrosine kinase inhibitors such as gefitinib …
Novel EGFR mutation-specific antibodies for lung adenocarcinoma: highly specific but not sensitive detection of an E746_A750 deletion in exon 19 and an L858R …
AN Seo, TI Park, Y Jin, PL Sun, H Kim, H Chang… - Lung Cancer, 2014 - Elsevier
Objectives Activating mutations in the epidermal growth factor receptor (EGFR) kinase
domain are correlated with dramatic clinical responses in non-small cell lung cancer …
domain are correlated with dramatic clinical responses in non-small cell lung cancer …
Rapid polymerase chain reaction-based detection of epidermal growth factor receptor gene mutations in lung adenocarcinomas
Somatic mutations in the tyrosine kinase domain of the epidermal growth factor receptor
(EGFR) gene are present in lung adenocarcinomas that respond to the EGFR inhibitors …
(EGFR) gene are present in lung adenocarcinomas that respond to the EGFR inhibitors …
[HTML][HTML] Novel epidermal growth factor receptor mutation-specific antibodies for non-small cell lung cancer: immunohistochemistry as a possible screening method for …
Y Kato, N Peled, MW Wynes, K Yoshida… - Journal of Thoracic …, 2010 - Elsevier
Background: Epidermal growth factor receptor (EGFR) mutations in non-small cell lung
cancer (NSCLC) predict better outcome to EGFR tyrosine kinase inhibitors. The most …
cancer (NSCLC) predict better outcome to EGFR tyrosine kinase inhibitors. The most …
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