The development of T-lymphocytes (T cells) constitute one of the basic and most vital
processes in immunology. Conventional mathematical models, being based on the systems …

Based on a previously developed theory of dysregulative lymphoma pathogenesis, an
advanced mathematical model was developed for simulation of thymic T cell populations …

Publisher Summary This chapter discusses the biology of T-cell receptor (TCR) activation,
proliferation, and homeostasis and explains the way in which mathematical approaches …

T-lymphocyte (T-cell) development constitutes one of the basic and most vital processes in
immunology. The process is profoundly affected by the thymic microenvironment, the …

We describe a coupled ordinary differential equation model of human T-cell proliferative
disorders based upon documented changes in various pools such as the bone marrow …

The immune system is a tremendously complicated and important system, whose central
players, the lymphocytes, are able to recognize specific foreign invaders (antigens) with their …

The thymus provides a stable microenvironment for post-natal thymocyte development that
is finely regulated by a complicated network of cytokines, chemokines, cell-cell contacts, etc …

Fundamental principles for the development of a biomathematical model of
lymphocytopoiesis are presented in this paper. The first step in this modeling approach is …

This computer model simulates the cell population kinetics of the development and later
degeneration of the thymus. Nutritional factors are taken into account by the growth of blood …

A number of mathematical models of cancer growth and treatment are presented. The most
significant model presented is of the interactions between a growing tumor and the immune …