Expression of membrane-associated NADPH oxidase (NOX1) represents a characteristic
feature of malignant cells. NOX1-derived extracellular superoxide anions are the basis for …

Increased reactive oxygen species (ROS) production has been detected in various cancers
and has been shown to have several roles, for example, they can activate pro-tumourigenic …

Tumor cells generate extracellular superoxide anions and are protected against intercellular
apoptosis-inducing HOCl-and NO/peroxynitrite signaling through the expression of …

Oncogenic transformation is dependent on activated membrane-associated NADPH oxidase
(NOX). However, the resultant extracellular superoxide anions are also driving the …

Significance: Reactive oxygen species (ROS) promote genomic instability, altered signal
transduction, and an environment that can sustain tumor formation and growth. The NOX …

Reactive oxygen species (ROS) exhibit procarcinogenic effects at multiple stages during
multistep oncogenesis. As a hallmark of the transformed state, extracellular superoxide …

Reactive oxygen species (ROS) localized at the precise subcellular compartments are
essential for regulating the activity of signaling proteins. Furthermore, ROS are master …

NADPH oxidases of the NADPH oxidase (NOX) family are dedicated reactive oxygen
species-generating enzymes that broadly and specifically regulate redox-sensitive …

ROS (reactive oxygen species) have long been regarded as a series of destructive
molecules that have a detrimental effect on cell homoeostasis. In support of this are the …

ROS include hydroxyl radicals (HO.), superoxide (O2..), and hydrogen peroxide (H2O2).
ROS are typically produced under physiological conditions and play crucial roles in living …