Background/Aim: Oncolytic adenoviruses (OAds) have attracted much attention as novel
anticancer therapeutics. The proper design of an expression cassette containing the E1A …

PURPOSE: Gene-attenuated replication-competent adenoviruses are emerging as a
promising new modality for the treatment of cancer. In an effort to continually improve upon …

ABSTRACT ONYX-015 is an attractive therapeutic adenovirus for cancer because it can
selectively replicate in tumor cells and kill them. To date, clinical trials of this adenovirus …

Gene-attenuated replication-competent adenoviruses are emerging as a promising new
modality for the treatment of cancer. For the aim of improving adenoviral vectors for cancer …

We have studied the oncolytic efficacy of two adenovirus vectors named KD3 and INGN 007,
which differ from each other only in that whereas KD3 has two small deletions in its e1a …

Oncolytic adenoviruses are promising anticancer agents due to their ability to self-amplify at
the tumor mass. However, tumor stroma imposes barriers difficult to overcome by these …

Gene-modified replication-competent adenoviruses (Ads) are emerging as a promising new
modality for the treatment of cancer. We have previously shown that E1B 19kDa and E1B …

Improving the antitumor potency of current oncolytic adenoviruses represents one of the
major challenges in development of these viruses for clinical use. We have generated an …

Background Oncolytic adenoviruses are promising agents for the multimodal treatment of
cancer. However, tumor-selectivity is crucial for their applicability in patients. Recent studies …

Simple Summary During high titer recombinant oncolytic adenovirus production, Replication-
Competent Adenovirus (RCA) contaminants can be generated through recombination …