Mesenchymal stem cells combined with IFNγ induce apoptosis of breast cancer cells partially through TRAIL

EN Yenilmez, D Genc, AA Farooqi, S Tunoglu… - Anticancer …, 2020 - ar.iiarjournals.org
Background: Mesenchymal stem cells (MSCs) have gained remarkable attention because of
their ability to dualistically regulate tumor growth. The main objective of this study was to …

[HTML][HTML] Activated human mesenchymal stem/stromal cells suppress metastatic features of MDA-MB-231 cells by secreting IFN-β

N Yoon, MS Park, T Shigemoto, G Peltier… - Cell death & disease, 2016 - nature.com
Our recent study showed that human mesenchymal stem/stromal cells (hMSCs) are
activated to express tumor necrosis factor (TNF)-α-related apoptosis-inducing ligand (TRAIL) …

IFN-γ-primed human bone marrow mesenchymal stem cells induce tumor cell apoptosis in vitro via tumor necrosis factor-related apoptosis-inducing ligand

J Du, L Zhou, X Chen, S Yan, M Ke, X Lu… - The international journal …, 2012 - Elsevier
Human mesenchymal stem cells hold promise as gene therapy vectors for delivery of
various genes to solid tumors for either therapeutic or tumor-tracing purposes. However …

[HTML][HTML] Irradiation enhances susceptibility of tumor cells to the antitumor effects of TNF-α activated adipose derived mesenchymal stem cells in breast cancer model

H Mohammadpour, AA Pourfathollah… - Scientific Reports, 2016 - nature.com
Gene modified or cytokine activated mesenchymal stem cells (MSCs) have been used as a
treatment in various types of cancer. Moreover, irradiation is usually applied as either a …

Anti-tumour effects of TRAIL-expressing human placental derived mesenchymal stem cells with curcumin-loaded chitosan nanoparticles in a mice model of triple …

M Kamalabadi-Farahani, M Vasei… - Artificial cells …, 2018 - Taylor & Francis
Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer with poor
prognosis. Despite the emergence of new and targeted therapies for other types of breast …

[HTML][HTML] Potential of mesenchymal stem cell based application in cancer

S Ramdasi, S Sarang… - International journal of …, 2015 - ncbi.nlm.nih.gov
Stem cell based treatments are being increasingly explored for their possible potential to
treat various cancers. Mesenchymal stem cells believed to possess anti-tumor potential and …

MSCTRAIL-mediated HepG2 cell death in direct and indirect co-cultures

XY Sun, J Nong, K Qin, H Lu, MR Moniri… - Anticancer …, 2011 - ar.iiarjournals.org
Background: Mesenchymal stem cells (MSCs) have attracted great interest in cancer therapy
since the discovery of their tumor tropism. This study was performed to investigate the effects …

Pre-activated human mesenchymal stromal cells in combination with doxorubicin synergistically enhance tumor-suppressive activity in mice

N Yoon, MS Park, GC Peltier, RH Lee - Cytotherapy, 2015 - Elsevier
Background aims Previously, we showed that human mesenchymal stromal cells (hMSCs)
were activated to express tumor necrosis factor (TNF)-related apoptosis-inducing ligand …

Direct and indirect effect of TNFα and IFNγ toward apoptosis in breast cancer cells

W Widowati, DK Jasaputra, SB Sumitro… - Molecular and …, 2018 - cellbiopharm.com
Background: Breast cancer (BC) is the leading cause of death cancer in women. Cancer
therapies using TNFα and IFNγ have been recently developed by direct effects and …

[HTML][HTML] Cytochalasin B-induced membrane vesicles from TRAIL-overexpressing mesenchymal stem cells induce extrinsic pathway of apoptosis in breast cancer …

DS Chulpanova, TV Pukhalskaia, ZE Gilazieva… - Current Issues in …, 2023 - mdpi.com
Tumor-necrosis-factor-associated apoptosis-inducing ligand (TRAIL) is one of the most
promising therapeutic cytokines that selectively induce apoptosis in tumor cells. It is known …