Overexpression of the pluripotent stem cell marker podocalyxin in prostate cancer

EI Heath, LK Heilbrun, D Smith… - Anticancer …, 2018 - ar.iiarjournals.org
Background/Aim: Podocalyxin, a member of the CD34 family of cell surface sialomucins, is
overexpressed in human embryonal carcinoma cell lines, as well as in several cancer types …

PcMab-47: novel antihuman podocalyxin monoclonal antibody for immunohistochemistry

S Ogasawara, MK Kaneko, S Yamada… - Monoclonal …, 2017 - liebertpub.com
Podocalyxin (PODXL) is a CD34-related sialomucin and a well-known marker of embryonic
stem cells. PODXL is expressed in many types of tumors including colorectal cancers, breast …

[HTML][HTML] Podocalyxin in normal tissue and epithelial cancer

N Le Tran, Y Wang, G Nie - Cancers, 2021 - mdpi.com
Simple Summary Malignancies derived from epithelial cells account for over 90% of all
human cancers. Several aspects of cancer progression such as metastasis, immune …

[HTML][HTML] Targeting a tumor-specific epitope on podocalyxin increases survival in human tumor preclinical models

D Canals Hernaez, MR Hughes, Y Li… - Frontiers in …, 2022 - frontiersin.org
Podocalyxin (Podxl) is a CD34-related cell surface sialomucin that is normally highly
expressed by adult vascular endothelia and kidney podocytes where it plays a key role in …

[HTML][HTML] Podocalyxin is a marker of poor prognosis in pancreatic ductal adenocarcinoma

K Saukkonen, J Hagström, H Mustonen, A Juuti… - PloS one, 2015 - journals.plos.org
Aim of the Study Podocalyxin-like 1 is a transmembrane glyco-protein whose
overexpression associates in many cancers with poor prognosis and unfavorable …

Podocalyxin expression in malignant astrocytic tumors

N Hayatsu, MK Kaneko, K Mishima, R Nishikawa… - Biochemical and …, 2008 - Elsevier
Podocalyxin is an anti-adhesive mucin-like transmembrane sialoglycoprotein that has been
implicated in the development of aggressive forms of cancer. Podocalyxin is also known as …

Podocalyxin in the diagnosis and treatment of cancer

KM McNagny, MR Hughes, ML Graves… - Advances in cancer …, 2012 - books.google.com
Although their functions in tumour development and progression are not well understood,
several secreted and membrane-associated mucins have proven to be valuable diagnostic …

[HTML][HTML] Podocalyxin enhances breast tumor growth and metastasis and is a target for monoclonal antibody therapy

KA Snyder, MR Hughes, B Hedberg, J Brandon… - Breast cancer …, 2015 - Springer
Introduction Podocalyxin (gene name PODXL) is a CD34-related sialomucin implicated in
the regulation of cell adhesion, migration and polarity. Upregulated expression of …

The TRA-1-60 and TRA-1-81 human pluripotent stem cell markers are expressed on podocalyxin in embryonal carcinoma

WM Schopperle, WC DeWolf - Stem cells, 2007 - academic.oup.com
We have previously identified the cell adhesion protein podocalyxin expressed in a human
pluripotent stem cell, embryonal carcinoma (EC), which is a malignant germ cell …

[HTML][HTML] A Cancer-Specific Monoclonal Antibody against Podocalyxin Exerted Antitumor Activities in Pancreatic Cancer Xenografts

H Suzuki, T Ohishi, T Tanaka, MK Kaneko… - International Journal of …, 2023 - mdpi.com
Podocalyxin (PODXL) overexpression is associated with poor clinical outcomes in various
tumors. PODXL is involved in tumor malignant progression through the promotion of …