Tissue harvesting for adoptive tumor infiltrating lymphocyte therapy in metastatic melanoma

D Zippel, O Friedman-Eldar, S Rayman… - Anticancer …, 2019 - ar.iiarjournals.org
Background/Aim: Adoptive transfer of tumor-infiltrating lymphocytes (TILs) combined with
non-myeloablative chemotherapy (NMA) has been shown to prolong survival in patients with …

Impact of clinical and pathologic features on tumor-infiltrating lymphocyte expansion from surgically excised melanoma metastases for adoptive T-cell therapy

RW Joseph, VR Peddareddigari, P Liu, PW Miller… - Clinical Cancer …, 2011 - AACR
Purpose: Clinical trials on adoptive T-cell therapy (ACT) using expanded tumor-infiltrating
lymphocytes (TIL) have shown response rates of over 50% in refractory melanoma …

Impact of prior treatment on the efficacy of adoptive transfer of tumor-infiltrating lymphocytes in patients with metastatic melanoma

SJ Seitter, RM Sherry, JC Yang, PF Robbins… - Clinical Cancer …, 2021 - AACR
Purpose: Adoptive cell transfer (ACT) of autologous tumor-infiltrating lymphocytes (TIL) can
mediate durable responses in patients with metastatic melanoma. This retrospective …

Adoptive cellular therapy for metastatic melanoma: the road to commercialization and treatment guidelines for clinicians

K Kooragayala, J Lou, YK Hong - Annals of Surgical Oncology, 2023 - Springer
Adoptive cell therapy (ACT) using tumor-infiltrating lymphocytes (TILs) has been gaining
promise as a therapeutic option for metastatic melanoma. By harnessing the power of …

Expanded tumor-infiltrating lymphocytes from soft tissue sarcoma have tumor-specific function

JE Mullinax, ML Hall, M Beatty, AM Weber… - Journal of …, 2021 - journals.lww.com
Adoptive cell transfer (ACT) with tumor-infiltrating lymphocytes (TILs) can generate durable
clinical responses in patients with metastatic melanoma and ongoing trials are evaluating …

Efficacy of single administration of tumor-infiltrating lymphocytes (TIL) in heavily pretreated patients with metastatic melanoma following checkpoint therapy.

A Sarnaik, HM Kluger, JA Chesney, J Sethuraman… - 2017 - ascopubs.org
3045 Background: Adoptive cell therapy with TIL involves collection of autologous
lymphocytes from the tumor via surgical resection, ex vivo expansion of TIL …

Adoptive transfer of tumor-infiltrating lymphocytes in patients with metastatic melanoma: intent-to-treat analysis and efficacy after failure to prior immunotherapies

MJ Besser, R Shapira-Frommer, O Itzhaki… - Clinical Cancer …, 2013 - AACR
Purpose: Adoptive cell transfer (ACT) using autologous tumor-infiltrating lymphocytes (TIL)
was reported to yield objective responses in about 50% of metastatic patients with …

[HTML][HTML] 36MO Location and size of metastasectomy in melanoma patients treated with tumor-infiltrating lymphocytes (TIL) in relation to clinical outcome

M Rohaan, TH Borch, R Kessels… - Immuno-Oncology …, 2022 - esmoiotech.org
Background Development of novel treatment options is essential for patients with metastatic
melanoma (MM), as about half derive no durable benefit upon first-line treatment. Adoptive …

Tumor infiltrating lymphocyte therapy for metastatic melanoma: analysis of tumors resected for TIL

SL Goff, FO Smith, JA Klapper, R Sherry… - Journal of …, 2010 - journals.lww.com
Adoptive cell transfer of tumor-infiltrating lymphocytes (TILs) can mediate objective tumor
regression in 49% to 72% of patients with many long-term durable responses. To undergo …

Comprehensive single institute experience with melanoma TIL: Long term clinical results, toxicity profile, and prognostic factors of response

MJ Besser, O Itzhaki, G Ben‐Betzalel… - Molecular …, 2020 - Wiley Online Library
Adoptive cell transfer (ACT) of tumor‐infiltrating lymphocytes (TIL) mediates objective
responses in 30% to 50% of patients with metastatic melanoma according to multiple, small …