Shift of keratin expression profile in end-stage kidney increases the risk of tumor development

DP Sarlos, L Peterfi, A Szanto, G Kovacs - Anticancer Research, 2018 - ar.iiarjournals.org
Background/Aim: Pre-neoplastic lesions and renal cell tumors of distinct pheno-and
genotypes occur frequently in end-stage kidneys. The aim of this study was to investigate the …

Clinical utility of keratin 14 expression measurement in reflecting the tumor properties and prognosis in patients with renal cell carcinoma: a study with long-term follow …

S Wang, P Gao, X Wang, L Duan, X He, J Qu - International Urology and …, 2024 - Springer
Abstract Purpose Keratin 14 (KRT14) is hypothesized to be involved in the pathogenesis of
renal cell carcinoma (RCC) based on its tumorigenic role in various cancers and its …

Clinical implication of keratin-15 quantification for renal cell carcinoma management: its dysregulation and association with clinicopathologic characteristics and …

W Zhang, P Chen, Z Li, R Zhang… - The Tohoku Journal of …, 2023 - jstage.jst.go.jp
Abstract Keratin-15 (KRT15) participates in the tumorigenesis of several cancers, especially
in urinary tract carcinomas by regulating basal urothelial cell malignant proliferation and …

Functional and Epigenetic Characterization of the KRT19 Gene in Renal Cell Neoplasms

F Paiva, S Duarte-Pereira, VL Costa… - DNA and cell …, 2011 - liebertpub.com
The KRT19 gene encodes cytokeratin 19, an element of the cytoskeleton whose expression
is frequently altered in renal cell carcinoma (RCC). Epigenetic phenomena, such as …

[HTML][HTML] KRT8 upregulation promotes tumor metastasis and is predictive of a poor prognosis in clear cell renal cell carcinoma

HS Tan, WH Jiang, Y He, DS Wang, ZJ Wu, DS Wu… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract Keratin 8 (KRT8) plays an essential role in the development and metastasis of
multiple human cancers. However, its role in clear cell renal cell carcinoma (ccRCC) …

[HTML][HTML] Dual role of KRT17: development of papillary renal cell tumor and progression of conventional renal cell carcinoma

DP Sarlos, MV Yusenko, L Peterfi, A Szanto… - Journal of …, 2019 - ncbi.nlm.nih.gov
Expression of KRT17 has been described in multi-layered epithelia as well as in tumors
derived from these cells. In cancers arising from KRT17 negative single layered epithelia …

[HTML][HTML] Keratins are novel markers of renal epithelial cell injury

S Djudjaj, M Papasotiriou, RD Bülow, A Wagnerova… - Kidney international, 2016 - Elsevier
Keratins, the intermediate filaments of the epithelial cell cytoskeleton, are up-regulated and
post-translationally modified in stress situations. Renal tubular epithelial cell stress is a …

Low expression of keratin17 is related to poor prognosis in bladder cancer

J Wu, H Xu, H Ji, B Zhai, J Zhu, M Gao… - OncoTargets and …, 2021 - Taylor & Francis
Objective To investigate the association between KRT17 and the prognosis in bladder
cancer patients. Methods The clinical data of 101 patients with bladder cancer from May …

Cytokeratin 18 expression pattern correlates with renal cell carcinoma progression: relationship with Snail

Y Messai, MZ Noman, A Derouiche… - International …, 2010 - spandidos-publications.com
Renal cell carcinoma (RCC) is the most common type of kidney cancer and recent
developments in the molecular biology of RCC have identified multiple pathways associated …

Keratin 17 knockdown suppressed malignancy and cisplatin tolerance of bladder cancer cells, as well as the activation of AKT and ERK pathway

C Li, HW Su, CG Ruan, XD Li - Folia histochemica et …, 2021 - journals.viamedica.pl
Abstract Introduction. Bladder cancer (BCa) is one the most common urinary system
malignancies and approximately one quarter of diagnosis is invasive muscle-invasive BCa …