Ampakines attenuate staurosporine-induced cell death in primary cortical neurons: implications in the 'chemo-brain'phenomenon

DP Radin, GA Rogers, KE Hewitt, R Purcell… - Anticancer …, 2018 - ar.iiarjournals.org
Background/Aim: Mounting evidence suggests that trophic cell signaling can be mediated by
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) activation. It …

Oncolytic properties of ampakines in vitro

DP Radin, R Purcell, AS Lippa - Anticancer Research, 2018 - ar.iiarjournals.org
Background/Aim: The 5-year survival rate of glioblastoma (GBM) is~ 10%, demonstrating
that a new therapeutic modality for this cancer is desperately needed. Complicating the …

BDNF mediates the neuroprotective effects of positive AMPA receptor modulators against MPP+-induced toxicity in cultured hippocampal and mesencephalic slices

H Jourdi, L Hamo, T Oka, A Seegan, M Baudry - Neuropharmacology, 2009 - Elsevier
Neurotoxicity is involved in various neurodegenerative diseases including Parkinson's
disease (PD), which affects mesencephalic dopaminergic neurons of the substantia nigra …

AMPA protects cultured neurons against glutamate excitotoxicity through a phosphatidylinositol 3‐kinase‐dependent activation in extracellular signal‐regulated …

X Wu, D Zhu, X Jiang, P Okagaki… - Journal of …, 2004 - Wiley Online Library
The signal transduction and molecular mechanisms underlying α‐amino‐3‐hydroxy‐5‐
methyl‐4‐isoxazole propionate (AMPA)‐mediated neuroprotection are unknown. In the …

Ampakines cause sustained increases in brain-derived neurotrophic factor signaling at excitatory synapses without changes in AMPA receptor subunit expression

JC Lauterborn, E Pineda, LY Chen, EA Ramirez… - Neuroscience, 2009 - Elsevier
Recent demonstrations that positive modulators of AMPA-type glutamate receptors
(ampakines) increase neuronal brain-derived neurotrophic factor (BDNF) expression have …

Chemotherapy‐induced cell death in primary cerebellar granule neurons but not in astrocytes: in vitro paradigm of differential neurotoxicity

A Wick, W Wick, J Hirrlinger, E Gerhardt… - Journal of …, 2004 - Wiley Online Library
The nervous system is frequently the site of symptomatic toxicity of antineoplastic agents.
However, there is limited information about the differential vulnerability of neurons …

Neuroprotective effects of agmatine in antineoplastic drugs induced neurotoxicity: In vitro study

D Binnetoglu, A Hacimuftuoglu, F Aricioglu - Life sciences, 2019 - Elsevier
Aims The effects of agmatine, an endogenous substance known to have a neuroprotective
effect against neurotoxicity has been investigated. Material and methods The primary …

Chronic elevation of brain-derived neurotrophic factor by ampakines

JC Lauterborn, GS Truong, M Baudry, X Bi… - … of Pharmacology and …, 2003 - ASPET
The ampakine CX614 positively modulates α-amino-3-hydroxy-5methyl-4-
isoxazolepropionic acid (AMPA) receptor-gated currents and increases brain-derived …

Positive modulation of AMPA receptors prevents downregulation of GluR2 expression and activates the Lyn‐ERK1/2‐CREB signaling in rat brain ischemia

QG Zhang, D Han, SQ Hu, C Li, CZ Yu, R Wang… - …, 2010 - Wiley Online Library
Abstract α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptors (AMPARs) are
responsible for excitotoxicity induced by ischemic injury in hippocampal CA1 neurons …

Adaptogens in chemobrain (Part II): Effect of plant extracts on chemotherapy-induced cytotoxicity in neuroglia cells

EJ Seo, SM Klauck, T Efferth, A Panossian - Phytomedicine, 2019 - Elsevier
Background Cancer chemotherapy-induced cognitive impairments are apparently
associated with harmful effects on physiological functions of brain cells. Adaptogens, are …