Intraperitoneal infusion of recombinant plasminogen activator inhibitor type 2 induced apoptosis in implanted human colon cancer and inhibited its growth and liver …

D Suwa, H Konno, T Tanaka, T Urano - Anticancer research, 2008 - ar.iiarjournals.org
Antitumor effects of plasminogen activator (PA) inhibitors (PAIs) were analyzed in a mouse
model of human colon cancer xenografts. Either recombinant PA inhibitor-1 (rPAI-1) or …

Protumorigenic activity of plasminogen activator inhibitor-1 through an antiapoptotic function

H Fang, VR Placencio… - Journal of the national …, 2012 - academic.oup.com
Background Plasminogen activator inhibitor-1 (PAI-1) is a protease inhibitor but is
paradoxically associated with poor outcomes in cancer patients. However, the mechanisms …

Pharmacokinetics and biodistribution of recombinant human plasminogen activator inhibitor type 2 (PAI-2) in control and tumour xenograft-bearing mice

MTN Hang, M Ranson, DN Saunders, XM Liang… - Fibrinolysis and …, 1998 - Elsevier
Objective: Previous studies have shown that the endogenous overexpression of human
plasminogen activator inhibitor type-2 (PAI-2) in tumour cells decrease their ability to grow …

Pharmacologic inhibition of PAI-1 increases apoptosis and inhibits macrophage migration in cancer.

VR Placencio, T Miyata, YA DeClerck - Cancer Research, 2013 - AACR
The paradoxical observation that elevated blood and tissue levels of plasminogen activator
inhibitor-1 (PAI-1) in cancer patients positively correlate with tumor progression supports a …

Plasminogen activator inhibitor 1 may promote tumour growth through inhibition of apoptosis

HC Kwaan, J Wang, K Svoboda, PJ Declerck - British journal of cancer, 2000 - nature.com
Abstract Plasminogen activator inhibitor 1 (PAI-1) has been found to be a bad prognostic
factor in a number of tumours but the reason has not been fully explained. The human …

Malignant transformation of wild-type but not plasminogen activator inhibitor-1 gene-deficient fibroblasts decreases cellular sensitivity to chemotherapy-mediated …

U Lademann, MU Rømer, PB Jensen… - European journal of …, 2005 - Elsevier
Plasminogen activator inhibitor-1 (PAI-1) inhibits the activation of the plasminogen activator
system, the latter being involved in cancer growth and dissemination. Interestingly, PAI-1 is …

Indication of a role of plasminogen activator inhibitor type 1 in protecting murine fibrosarcoma cells against apoptosis

MU Rømer, AK Due, JK Larsen… - Thrombosis and …, 2005 - thieme-connect.com
In a number of cancer types high tumor tissue levels of plasminogen activator inhibitor type 1
(PAI-1) protein are strongly associated with shorter cancer patient survival. This association …

Inhibition of invasion of HT1080 sarcoma cells expressing recombinant plasminogen activator inhibitor 2

WE Laug, XR Cao, YB Yu, H Shimada, EKO Kruithof - Cancer research, 1993 - AACR
Plasminogen activators (PA) elaborated by tumor cells play an important role in the complex
process of tissue invasion and metastasis. In the present study the effect of the PA inhibitor …

Regulation of programmed cell death by plasminogen activator inhibitor type 1 (PAI-1)

UA Lademann, MU Rømer - Thrombosis and haemostasis, 2008 - thieme-connect.com
Elevated levels of plasminogen activator inhibitor-1 (PAI-1) are associated with poor
prognosis in cancer. An explanation to the elevated levels of PAI-1 could be a protective …

Plasminogen activator inhibitor type 1 (PAI-1) in cancer: a potential new target for antiinvasive and antimetastatic therapy

TL Frandsen, RW Stephens, AN Pedersen… - Drugs of the …, 1998 - access.portico.org
Cancer cells must degrade extracellular matrix proteins in order to invade and subsequently
metastasize. There is today sufficient experimental and clinical evidence for a critical role of …