Elevated expression of IRS2 in the progression from neurofibroma to malignant peripheral nerve sheath tumor
CM Shaw, SR Grobmyer, DA Ucar, WG Cance… - Anticancer …, 2012 - ar.iiarjournals.org
Background/Aim: Novel drugs to inhibit insulin receptor substrate (IRS) and focal adhesion
kinase (FAK) pathways are emerging and will be sarcoma subtype-specific. As a result …
kinase (FAK) pathways are emerging and will be sarcoma subtype-specific. As a result …
Expression of insulin-like growth-factor-1 receptor (IGF-1R) in peripheral nerve sheath tumors in neurofibromatosis type 1
RE Friedrich, D Keiner, C Hagel - Anticancer research, 2007 - ar.iiarjournals.org
Background: Neurofibromatosis type 1 (NF1) is an autosomal-dominant inherited disease,
characterised by the development of nerve sheath tumors. NF1 is the most frequently …
characterised by the development of nerve sheath tumors. NF1 is the most frequently …
Expression of Ras signaling pathway proteins and developmental factors in peripheral nerve sheath tumors of patients with neurofibromatosis type 1
C Hagel, LKN Nörnberg… - Clinical …, 2023 - search.proquest.com
Purpose: To characterize expression of factors relevant for Ras signaling and
developmental factors in a large series of peripheral nerve sheath tumors (PNST) obtained …
developmental factors in a large series of peripheral nerve sheath tumors (PNST) obtained …
ERBB2 and ERBB3 growth factor receptors, neuregulin-1, CD44 and Ki-67 proliferation index in neurofibromatosis type 1-associated peripheral nerve sheath tumors
RE Friedrich, LKN Noernberg, C Hagel - Anticancer Research, 2022 - ar.iiarjournals.org
Aim: To characterize the growth pattern and antigen profile of peripheral nerve sheaths
tumors (PNST) in a large series of tumors obtained from patients with neurofibromatosis type …
tumors (PNST) in a large series of tumors obtained from patients with neurofibromatosis type …
Genomic and molecular characterization of malignant peripheral nerve sheath tumor identifies the IGF1R pathway as a primary target for treatment
Purpose: Malignant peripheral nerve sheath tumor (MPNST) is a rare sarcoma that lacks
effective therapeutic strategies. We gain insight into the most recurrent genetically altered …
effective therapeutic strategies. We gain insight into the most recurrent genetically altered …
Differentially expressed genes in neurofibromatosis 1-associated neurofibromas and malignant peripheral nerve sheath tumors
N Holtkamp, VF Mautner, RE Friedrich, A Harder… - Acta …, 2004 - Springer
Neurofibromas represent one of the hallmarks of neurofibromatosis 1 (NF1) patients. Tumor
progression of neurofibromas to malignant peripheral nerve sheath tumors (MPNST) is a …
progression of neurofibromas to malignant peripheral nerve sheath tumors (MPNST) is a …
EGFR–STAT3 signaling promotes formation of malignant peripheral nerve sheath tumors
J Wu, DM Patmore, E Jousma, DW Eaves, K Breving… - Oncogene, 2014 - nature.com
Malignant peripheral nerve sheath tumors (MPNSTs) develop sporadically or in the context
of neurofibromatosis type 1. Epidermal growth factor receptor (EGFR) overexpression has …
of neurofibromatosis type 1. Epidermal growth factor receptor (EGFR) overexpression has …
STAT3 and HIF1α signaling drives oncogenic cellular phenotypes in malignant peripheral nerve sheath tumors
Therapeutic options are limited for neurofibromatosis type 1 (NF1)-associated malignant
peripheral nerve sheath tumors (MPNST) and clinical trials using drug agents have so far …
peripheral nerve sheath tumors (MPNST) and clinical trials using drug agents have so far …
[HTML][HTML] Neurofibromin Deficiency Causes Epidermal Growth Factor Receptor Upregulation through the Activation of Ras/ERK/SP1 Signaling Pathway in …
GH Park, SJ Lee, CG Lee, J Kim, E Park… - International Journal of …, 2021 - mdpi.com
Neurofibromatosis type 1 (NF1) is an autosomal dominant human genetic disorder. The
progression of benign plexiform neurofibromas to malignant peripheral nerve sheet tumors …
progression of benign plexiform neurofibromas to malignant peripheral nerve sheet tumors …
Expression and significance of EGFR in malignant peripheral nerve sheath tumor
D Keizman, J Issakov, I Meller, N Meimon… - Journal of neuro …, 2009 - Springer
Malignant peripheral nerve sheath tumor (MPNST) is an aggressive sarcoma. Epidermal
growth factor receptor (EGFR) may play a putative role in its pathogenesis, and be targeted …
growth factor receptor (EGFR) may play a putative role in its pathogenesis, and be targeted …