Background: The hedgehog signaling pathway (HH) is involved in tumorigenesis in a variety
of human malignancies. In head and neck squamous cell carcinomas (HNSCC), Hh …

Background: Overexpression of the Hedgehog (HH) signalling pathway has been described
in several malignancies and is associated with a poor prognosis. HH signalling blockade …

Deregulation of crucial embryonic pathways, including hedgehog signaling, has been
frequently implicated in a variety of human cancers and is emerging as an important target …

Head and neck squamous cell carcinoma (HNSCC) is the sixth leading malignancy
worldwide, with a poor prognosis and limited treatment options. Molecularly targeted …

Abstract The Hedgehog (Hh) pathway has been implicated in a wide variety of human
tumors, and early clinical trials with pathway antagonists have validated Hh signaling as a …

Excessive activation of the hedgehog (Hh) signaling pathway is important in a variety of
human cancer cell types, including gastric cancer. However, the underlying mechanisms of …

Abstract The Hedgehog (Hh) signaling pathway functions as an organizer in embryonic
development. Genetic analysis has demonstrated a critical role for the Hh pathway in …

Chemoresistant metastases of osteosarcoma in humans limit survival in approximately one
third of patients. Furthermore, aggressive chemotherapy can lead to side effects and …

The Hedgehog (Hh) signaling pathway directs the development of multiple tissues during
embryonic development, and contributes to tissue homeostasis in adults. Deficient Hh …

The Hedgehog (Hh) signaling pathway has been shown to be involved in the development
of several different types of human cancers. Novel findings suggest that Hh regulates key …