The in vitro and in vivo activity of the microtubule disruptor STX140 is mediated by Hif-1 alpha and CAIX expression
C Stengel, SP Newman, MP Leese… - Anticancer …, 2015 - ar.iiarjournals.org
Tumor neo-angiogenesis is regulated, in part, by the hypoxia-inducible gene HIF1. Evidence
suggests HIF1 associates with polymerized microtubules and traffics to the nucleus. This …
suggests HIF1 associates with polymerized microtubules and traffics to the nucleus. This …
Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1α accumulation and activity by disrupting microtubule function
D Escuin, ER Kline, P Giannakakou - Cancer research, 2005 - AACR
We have recently identified a mechanistic link between disruption of the microtubule
cytoskeleton and inhibition of tumor angiogenesis via the hypoxia-inducible factor-1 (HIF-1) …
cytoskeleton and inhibition of tumor angiogenesis via the hypoxia-inducible factor-1 (HIF-1) …
[HTML][HTML] M410, a combretastatin A4 analogue, disrupts microtubules and inhibits HIF-1α in human breast cancer cells
H Yang, Q Xia, Y Zou, K Wang… - Oncology …, 2015 - spandidos-publications.com
Abstract Hypoxia-inducible factor-1 (HIF-1) is a primary transcriptional factor that targets a
series of genes participating in angiogenesis and cell proliferation. HIF-1 is a heterodimer …
series of genes participating in angiogenesis and cell proliferation. HIF-1 is a heterodimer …
[HTML][HTML] ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma (HCC) cells, and inhibits growth and …
C Moser, SA Lang, A Mori, C Hellerbrand, HJ Schlitt… - BMC cancer, 2008 - Springer
Background Hepatocellular carcinoma (HCC) represents a highly vascularized tumor entity
and the process of angiogenesis is essential for the growth of HCC. Importantly, the pro …
and the process of angiogenesis is essential for the growth of HCC. Importantly, the pro …
[HTML][HTML] Microtubules regulate hypoxia-inducible factor-1α protein trafficking and activity: implications for taxane therapy
M Carbonaro, D Escuin, A O'Brate… - Journal of Biological …, 2012 - ASBMB
Disruption of the microtubule cytoskeleton impairs tumor angiogenesis by inhibiting the
hypoxia-inducible factor (HIF-1α) pathway. However, the signaling cascade linking …
hypoxia-inducible factor (HIF-1α) pathway. However, the signaling cascade linking …
A novel microtubule-modulating agent EM011 inhibits angiogenesis by repressing the HIF-1α axis and disrupting cell polarity and migration
Endothelial tubular morphogenesis relies on an exquisite interplay of microtubule dynamics
and actin remodeling to propel directed cell migration. Recently, the dynamicity and integrity …
and actin remodeling to propel directed cell migration. Recently, the dynamicity and integrity …
Anti-tumor activity and mechanisms of a novel vascular disrupting agent,(Z)-3, 4′, 5-trimethoxylstilbene-3′-O-phosphate disodium (M410)
YC Cai, Y Zou, YL Ye, HY Sun, QG Su, ZX Wang… - Investigational new …, 2011 - Springer
Vascular disrupting agents (VDAs) have emerged as a new kind of anti-cancer drug in
recent years. Structural modification of an active parent compound is an effective approach …
recent years. Structural modification of an active parent compound is an effective approach …
A-432411, a novel indolinone compound that disrupts spindle pole formation and inhibits human cancer cell growth
Z Chen, PJ Merta, NH Lin, SK Tahir, P Kovar… - Molecular cáncer …, 2005 - AACR
Microtubules are among the most successful targets for anticancer therapies and for the
development of new anticancer drugs. A-432411 is a novel small molecule that destabilizes …
development of new anticancer drugs. A-432411 is a novel small molecule that destabilizes …
A tumoural angiogenic gateway blocker, Benzophenone-1B represses the HIF-1α nuclear translocation and its target gene activation against neoplastic progression
Hypoxia is an important module in all solid tumours to promote angiogenesis, invasion and
metastasis. Stabilization and subsequent nuclear localization of HIF-1α subunits result in the …
metastasis. Stabilization and subsequent nuclear localization of HIF-1α subunits result in the …
Noscapine inhibits hypoxia-mediated HIF-1α expression andangiogenesis in vitro: a novel function for an old drug
EW Newcomb, Y Lukyanov… - International …, 2006 - spandidos-publications.com
Overexpression of hypoxia-inducible factor-1 (HIF-1) is a common feature in solid
malignancies related to oxygen deficiency. Since increased HIF-1 expression correlates with …
malignancies related to oxygen deficiency. Since increased HIF-1 expression correlates with …