Antitumor activity of acriflavine in lung adenocarcinoma cell line A549
Aim/Materials and Methods: In order to develop better drugs against non-small cell lung
cancer (NSCLC), we screened a variety of compounds and treated the human lung …
cancer (NSCLC), we screened a variety of compounds and treated the human lung …
Antitumor activity of acriflavine in human hepatocellular carcinoma cells
CJ Lee, CH Yue, YY Lin, JC Wu, JY Liu - Anticancer research, 2014 - ar.iiarjournals.org
Patients suffering from advanced hepatocellular carcinoma can generally be treated only by
targeted therapy to achieve a survival rate that lasts a few months more than that achieved …
targeted therapy to achieve a survival rate that lasts a few months more than that achieved …
Effects of guanosine on the pharmacokinetics of acriflavine in rats following the administration of a 1: 1 mixture of acriflavine and guanosine, a potential antitumor …
PS Lee, DH Shin, KM Lee, S Song, HS Yoo… - Archives of pharmacal …, 2007 - Springer
Preclinical studies are currently underway to examine the potential antitumor effects of a 1: 1
mixture of acriflavine (ACF; CAS 8063-24-9) and guanosine. Guanosine potentiates the anti …
mixture of acriflavine (ACF; CAS 8063-24-9) and guanosine. Guanosine potentiates the anti …
Enhanced Anti‐tumour Effects of Acriflavine in Combination with Guanosine in Mice
SG Kim, CW Kim, ETAY AHN, KY LEE… - Journal of pharmacy …, 1997 - Wiley Online Library
The anti‐tumour activity of acriflavine in combination with guanosine has been evaluated in
solid or ascitic tumour‐implanted animal models. Guanosine is known to potentiate the anti …
solid or ascitic tumour‐implanted animal models. Guanosine is known to potentiate the anti …
[HTML][HTML] The activation of the tumor suppressor protein p53 by acriflavine leads to mitochondrial dysfunction and improves the radiosensitivity of colon cancer cells
C Lin, X Chen, H Qiu, B Li, M Guo - Journal of Immunology Research, 2022 - hindawi.com
Colon cancer ranks third worldwide, and it has a growing incidence with urbanization and
industrialization. Drug resistance in colon cancer is gradually affecting the treatment. This …
industrialization. Drug resistance in colon cancer is gradually affecting the treatment. This …
Novel tetrahydroacridine derivatives inhibit human lung adenocarcinoma cell growth by inducing G1 phase cell cycle arrest and apoptosis
P Olszewska, E Mikiciuk-Olasik… - Biomedicine & …, 2014 - Elsevier
Lung cancer is not only the most commonly diagnosed cancers worldwide but it is still the
leading cause of cancer-related death. Acridine derivatives are a class of anticancer agents …
leading cause of cancer-related death. Acridine derivatives are a class of anticancer agents …
Pharmacokinetics of guanosine in rats following intravenous or intramuscular administration of a 1: 1 mixture of guanosine and acriflavine, a potential antitumor agent
DH Shin, KS Choi, BS Cho, S Song, DC Moon… - Archives of pharmacal …, 2008 - Springer
Abstract A 1: 1 mixture of acriflavine (ACF; CAS 8063-24-9) and guanosine is under
evaluation in preclinical studies as a possible antitumor agent. Guanosine is known to …
evaluation in preclinical studies as a possible antitumor agent. Guanosine is known to …
Novel tetrahydroacridine and cyclopentaquinoline derivatives with fluorobenzoic acid moiety induce cell cycle arrest and apoptosis in lung cancer cells by activation of …
P Szymański, P Olszewska, E Mikiciuk-Olasik… - Tumor …, 2017 - journals.sagepub.com
Lung cancer is still the leading cause of cancer-related death worldwide, indicating a
necessity to develop more effective therapy. Acridine derivatives are potential anticancer …
necessity to develop more effective therapy. Acridine derivatives are potential anticancer …
[HTML][HTML] Acriflavine enhances the antitumor activity of the chemotherapeutic drug 5‑fluorouracil in colorectal cancer cells
P Zargar, E Ghani, FJ Mashayekhi… - Oncology …, 2018 - spandidos-publications.com
Fluorouracil (5‑FU)‑based chemotherapy improves the overall survival rates of patients with
colorectal cancer (CRC). However, only a small proportion of patients respond to 5‑FU when …
colorectal cancer (CRC). However, only a small proportion of patients respond to 5‑FU when …
9-phenyl acridine exhibits antitumour activity by inducing apoptosis in A375 cells
Several acridine derivatives have been screened for their therapeutic potential and some
are already established as antiprotozoan, antibacterial or anticancer agents. However …
are already established as antiprotozoan, antibacterial or anticancer agents. However …