Antitumor activity of acriflavine in lung adenocarcinoma cell line A549

CJ Lee, CH Yue, YJ Lin, YY Lin, SH Kao… - Anticancer …, 2014 - ar.iiarjournals.org
Aim/Materials and Methods: In order to develop better drugs against non-small cell lung
cancer (NSCLC), we screened a variety of compounds and treated the human lung …

Antitumor activity of acriflavine in human hepatocellular carcinoma cells

CJ Lee, CH Yue, YY Lin, JC Wu, JY Liu - Anticancer research, 2014 - ar.iiarjournals.org
Patients suffering from advanced hepatocellular carcinoma can generally be treated only by
targeted therapy to achieve a survival rate that lasts a few months more than that achieved …

Effects of guanosine on the pharmacokinetics of acriflavine in rats following the administration of a 1: 1 mixture of acriflavine and guanosine, a potential antitumor …

PS Lee, DH Shin, KM Lee, S Song, HS Yoo… - Archives of pharmacal …, 2007 - Springer
Preclinical studies are currently underway to examine the potential antitumor effects of a 1: 1
mixture of acriflavine (ACF; CAS 8063-24-9) and guanosine. Guanosine potentiates the anti …

Enhanced Anti‐tumour Effects of Acriflavine in Combination with Guanosine in Mice

SG Kim, CW Kim, ETAY AHN, KY LEE… - Journal of pharmacy …, 1997 - Wiley Online Library
The anti‐tumour activity of acriflavine in combination with guanosine has been evaluated in
solid or ascitic tumour‐implanted animal models. Guanosine is known to potentiate the anti …

[HTML][HTML] The activation of the tumor suppressor protein p53 by acriflavine leads to mitochondrial dysfunction and improves the radiosensitivity of colon cancer cells

C Lin, X Chen, H Qiu, B Li, M Guo - Journal of Immunology Research, 2022 - hindawi.com
Colon cancer ranks third worldwide, and it has a growing incidence with urbanization and
industrialization. Drug resistance in colon cancer is gradually affecting the treatment. This …

Novel tetrahydroacridine derivatives inhibit human lung adenocarcinoma cell growth by inducing G1 phase cell cycle arrest and apoptosis

P Olszewska, E Mikiciuk-Olasik… - Biomedicine & …, 2014 - Elsevier
Lung cancer is not only the most commonly diagnosed cancers worldwide but it is still the
leading cause of cancer-related death. Acridine derivatives are a class of anticancer agents …

Pharmacokinetics of guanosine in rats following intravenous or intramuscular administration of a 1: 1 mixture of guanosine and acriflavine, a potential antitumor agent

DH Shin, KS Choi, BS Cho, S Song, DC Moon… - Archives of pharmacal …, 2008 - Springer
Abstract A 1: 1 mixture of acriflavine (ACF; CAS 8063-24-9) and guanosine is under
evaluation in preclinical studies as a possible antitumor agent. Guanosine is known to …

Novel tetrahydroacridine and cyclopentaquinoline derivatives with fluorobenzoic acid moiety induce cell cycle arrest and apoptosis in lung cancer cells by activation of …

P Szymański, P Olszewska, E Mikiciuk-Olasik… - Tumor …, 2017 - journals.sagepub.com
Lung cancer is still the leading cause of cancer-related death worldwide, indicating a
necessity to develop more effective therapy. Acridine derivatives are potential anticancer …

[HTML][HTML] Acriflavine enhances the antitumor activity of the chemotherapeutic drug 5‑fluorouracil in colorectal cancer cells

P Zargar, E Ghani, FJ Mashayekhi… - Oncology …, 2018 - spandidos-publications.com
Fluorouracil (5‑FU)‑based chemotherapy improves the overall survival rates of patients with
colorectal cancer (CRC). However, only a small proportion of patients respond to 5‑FU when …

9-phenyl acridine exhibits antitumour activity by inducing apoptosis in A375 cells

R Ghosh, S Bhowmik, D Guha - Molecular and cellular biochemistry, 2012 - Springer
Several acridine derivatives have been screened for their therapeutic potential and some
are already established as antiprotozoan, antibacterial or anticancer agents. However …