Kindlin-3 in Immune Cells Is Required to Suppress Prostate Cancer Tumor Growth in Mice

C Liu, Y Zhou, YU Zhou, Z Xu, YQ Ma - Anticancer Research, 2022 - ar.iiarjournals.org
Background/Aim: Kindlins are essential integrin activators. Kindlin-1 and kindlin-2 are often
concomitantly expressed in epithelial tumor cells and participate in regulating tumor …

[HTML][HTML] Distinct expression profiles and functions of Kindlins in breast cancer

P Azorin, F Bonin, A Moukachar, A Ponceau… - Journal of Experimental …, 2018 - Springer
Abstract Background Kindlin-1,− 2, and− 3 are the three members of the Kindlin family. They
are best known as regulators of integrin functions, contributing to fundamental biological …

[HTML][HTML] Of kindlins and cancer

EF Plow, M Das, K Bialkowska, K Sossey-Alaoui - Discoveries, 2016 - ncbi.nlm.nih.gov
Abstract Kindlins are 4.1-ezrin-ridixin-moesin (FERM) domain containing proteins. There are
three kindlins in mammals, which share high sequence identity. Kindlin-1 is expressed …

Kindlin‐2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration

Z An, K Dobra, JG Lock, S Strömblad… - … journal of cancer, 2010 - Wiley Online Library
Kindlin‐2 is a novel integrin‐interacting focal adhesion protein that belongs to the Kindlin
family. Focal adhesion proteins control cytoskeleton dynamics and promote cancer cell …

[HTML][HTML] Opposite role of Kindlin-1 and Kindlin-2 in lung cancers

J Zhan, X Zhu, Y Guo, Y Wang, Y Wang, G Qiang… - PloS one, 2012 - journals.plos.org
Lung cancer is highly heterogenous and is composed of various subtypes that are in diverse
differential stages. The newly identified integrin-interacting proteins Kindlin-1 and Kindlin-2 …

[HTML][HTML] Effects of increased Kindlin-2 expression in bladder cancer stromal fibroblasts

J Wu, C Yu, L Cai, Y Lu, L Jiang, C Liu, Y Li, F Feng… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Kindlin-2 is a focal adhesion protein highly expressed in bladder cancer stromal fibroblasts.
We investigated the prognostic significance of Kindlin-2 in bladder cancer stromal fibroblasts …

Kindlin-1 regulates IL-6 secretion and modulates the immune environment in breast cancer models

ER Webb, GL Dodd, M Noskova, E Bullock, M Muir… - Elife, 2023 - elifesciences.org
The adhesion protein Kindlin-1 is over-expressed in breast cancer where it is associated
with metastasis-free survival; however, the mechanisms involved are poorly understood …

Kindlin-2 promotes invasiveness of prostate cancer cells via NF-κB-dependent upregulation of matrix metalloproteinases

J Yang, T Pan, H Yang, T Wang, W Liu, B Liu, W Qian - Gene, 2016 - Elsevier
Invasive progression is the major lethal cause of prostate cancer. In this study, we aimed to
investigate the role of kindlin-2, an integrin-binding focal adhesion protein, in the regulation …

[HTML][HTML] Kindlin‐1 drives early steps of breast cancer metastasis

F Bonin, A Chiche, Z Tariq, P Azorin, S Nola… - Cancer …, 2022 - ncbi.nlm.nih.gov
Dear Editor, Kindlin-1 plays a major role in the activation of integrins [1]. Kindlin-1 is often
overexpressed in cancers. Kindlin-1 overexpression has been associated with a higher …

[HTML][HTML] A feedback regulation between Kindlin-2 and GLI1 in prostate cancer cells

J Gao, AA Khan, T Shimokawa, J Zhan, S Strömblad… - FEBS letters, 2013 - Elsevier
Kindlin-2 is engaged in tumor progression. However, the mechanism accounting for Kindlin-
2 regulation in tumor cells remained largely unknown. Here, we report a regulatory loop …