Antiproliferative and apoptosis-inducing activity of nobiletin against three subtypes of human breast cancer cell lines

C Chen, M Ono, M Takeshima, S Nakano - Anticancer research, 2014 - ar.iiarjournals.org
Although nobiletin has a potent antitumor activity against several types of human cancers, its
inhibitory effects and possible mechanisms of action on breast cancer cells with different …

[PDF][PDF] Nobiletin increased cytotoxic activity of doxorubicin on MCF-7 cells but not on T47D cells

E Meiyanto, A Hermawan, S Junedi… - International Journal …, 2011 - researchgate.net
Nobiletin, a citrus flavonoid, shows strong cytotoxic effect in several cancer cell lines. The
aim of this research was to investigate cytotoxic activities of nobiletin alone and in …

Nobiletin in cancer therapy; mechanisms and therapy perspectives

R Moazamiyanfar, S Rezaei… - Current …, 2023 - ingentaconnect.com
Cancer has remained to be one of the major challenges in medicine and regarded as the
second leading cause of death worldwide. Different types of cancer may resist anti-cancer …

Inhibitory Effects of Nobiletin on Hepatocellular Carcinoma In Vitro and In Vivo

X Ma, S Jin, Y Zhang, L Wan, Y Zhao… - Phytotherapy …, 2014 - Wiley Online Library
Nobiletin (5, 6, 7, 8, 3′ 4′‐hexamethoxyflavone) is a major anticancer component in juice
from zhishi (Rutaceae). This study aimed to investigate the inhibitory effect of Nobiletin on …

Nobiletin inhibits breast cancer cell migration and invasion by suppressing the IL-6-induced ERK-STAT and JNK-c-JUN pathways

Y Wu, Q Li, L Lv, J Chen, H Ying, M Ruan, W Zhu, J Xu… - Phytomedicine, 2023 - Elsevier
Background Breast cancer is one of the most common cancers in women, affecting more
than 2 million women worldwide annually. However, effective treatments for breast cancer …

Nobiletin suppresses the proliferation and induces apoptosis involving MAPKs and caspase-8/-9/-3 signals in human acute myeloid leukemia cells

PC Hsiao, WJ Lee, SF Yang, P Tan, HY Chen, LM Lee… - Tumor Biology, 2014 - Springer
Nobiletin, a compound isolated from citrus fruits, is a polymethoxylated flavone derivative
that was shown to have anti-inflammatory and anticancer activities in various solid tumors …

Nobiletin promotes the pyroptosis of breast cancer via regulation of miR‐200b/JAZF1 axis

JG Wang, WJ Jian, Y Li, J Zhang - The Kaohsiung journal of …, 2021 - Wiley Online Library
Nobiletin is a polymethoxylated flavone present in citrus fruits, which has been reported to
have inhibitory effects on tumorigenesis of cancers. However, the biological function of …

Nobiletin as an inducer of programmed cell death in cancer: a review

J Huang, Z Chang, Q Lu, X Chen, M Najafi - Apoptosis, 2022 - Springer
Cancer resistance to therapy is a big issue in cancer therapy. Tumours may develop some
mechanisms to reduce the induction of cell death, thus stimulating tumour growth. Cancer …

[HTML][HTML] Nobiletin in cancer therapy: How this plant derived-natural compound targets various oncogene and onco-suppressor pathways

M Ashrafizadeh, A Zarrabi, S Saberifar, F Hashemi… - Biomedicines, 2020 - mdpi.com
Cancer therapy is a growing field, and annually, a high number of research is performed to
develop novel antitumor drugs. Attempts to find new antitumor drugs continue, since cancer …

Nobiletin induces apoptosis and potentiates the effects of the anticancer drug 5-fluorouracil in p53-mutated SNU-16 human gastric cancer cells

JY Moon, M Cho, KS Ahn, SK Cho - Nutrition and cancer, 2013 - Taylor & Francis
Nobiletin is a typical polymethoxyl flavone from citrus fruits that has anticancer properties,
but the molecular mechanism of its inhibitory effects on the growth of p53-mutated SNU-16 …