Bcl-2-like protein 11 (BIM) expression is associated with favorable prognosis for patients with cervical cancer

BW Kim, H Cho, K Ylaya, H Kitano, JY Chung… - Anticancer …, 2017 - ar.iiarjournals.org
Background/Aim: Bcl-2-like protein 11 (BIM) is a pro-apoptotic member of the Bcl-2 protein
family. BIM elicits cell death by binding to pro-survival Bcl-2 proteins. Even though the …

Bim may be a poor prognostic biomarker in breast cancer patients especially in those with luminal A tumors

Y Maimaiti, L Dong, A Aili, M Maimaitiaili… - Cancer …, 2017 - content.iospress.com
BACKGROUND: Bcl-2 interacting mediator of cell death (Bim) appears to have contradictory
roles in cancer. It is uncertain whether Bim show prognostic significance in patients with …

[HTML][HTML] Bim expression is reduced in human cutaneous melanomas

DL Dai, Y Wang, M Liu, M Martinka, G Li - Journal of investigative …, 2008 - Elsevier
Bim is a BH3-only protein belonging to the Bcl-2 family of apoptotic regulators. Upon
activation, Bim can antagonize all the prosurvival Bcl-2 proteins, leading to apoptosis. To …

Identification and characterization of BH3 domain protein Bim and its isoforms in human hepatocellular carcinomas

J Miao, GG Chen, JP Yun, SY Chun, ZZ Zheng, RLK Ho… - Apoptosis, 2007 - Springer
BH3-only protein Bim is a critical regulator of apoptosis and plays an essential role in
mammalian development, but the characterization of Bim and its isoforms in hepatocellular …

[HTML][HTML] Expression of Bim, Noxa, and Puma in non-small cell lung cancer

J Sakakibara-Konishi, S Oizumi, J Kikuchi, E Kikuchi… - BMC cancer, 2012 - Springer
Background The BH3-only members of the Bcl-2 protein family have been proposed to play
a key role in the control of apoptosis and in the initiation of the apoptotic pathways. In this …

[PDF][PDF] Different gene expression profiles of AD293 and HEK293 cell lines that show contrasting susceptibility to apoptosis induced by overexpression of Bim L

J Zhang, J Chen, L Liu, C Ji, S Gu, K Ying… - Acta Biochimica …, 2006 - bibliotekanauki.pl
Bim is a pro-apoptotic member of the Bcl-2 protein family. Overexpression of Bim proved to
be highly cytotoxic for diverse cells. The AD293 cell line is derived directly from the HEK293 …

[HTML][HTML] Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer

R Gogada, N Yadav, J Liu, S Tang, D Zhang… - Journal of Biological …, 2013 - ASBMB
Proapoptotic Bcl-2 homology 3-only protein Bim plays an important role in Bax/Bak-
mediated cytochrome c release and apoptosis. Here, we provide evidence for a novel …

Identification and characterization of Bimγ, a novel proapoptotic BH3-only splice variant of Bim

JW Liu, D Chandra, SH Tang, D Chopra, DG Tang - Cancer research, 2002 - AACR
Abstract BH3 (Bcl-2 homology 3)-only proteins of the Bcl-2 family play an essentialrole in
apoptosis. In this study, a novel human BH3-only protein, Bcl-2-interacting mediator (Bim) γ …

BH3-only protein BIM: An emerging target in chemotherapy

S Shukla, S Saxena, BK Singh, P Kakkar - European journal of cell biology, 2017 - Elsevier
BH3-only proteins constitute major proportion of pro-apoptotic members of B-cell lymphoma
2 (Bcl-2) family of apoptotic regulatory proteins and participate in embryonic development …

Over-expression of Bim α3, a novel isoform of human Bim, result in cell apoptosis

JZ Chen, CN Ji, SH Gu, JX Li, EP Zhao, Y Huang… - … International Journal of …, 2004 - Elsevier
Bim proteins are essential factors of apoptosis. Nine isoforms of Bim have been submitted to
GenBank database. In order to improve the understanding of the regulation of Bims' …