Cytidine-phosphate-guanosine oligodeoxynucleotides and interferon-alpha-expressing tumor cells effectively induce dendritic cell maturation in vitro

A Hiraide, K Hiroishi, S Ishii, J Eguchi… - Anticancer …, 2006 - ar.iiarjournals.org
Background: Dendritic cells (DCs) play an important role in immune response and cytidine-
phosphate-guanosine (CpG) oligodeoxynucleotides (ODN) as well as interferon (IFN)-α …

Dendritic cells stimulated with cytidine‐phosphate‐guanosine oligodeoxynucleotides and interferon‐α‐expressing tumor cells effectively reduce outgrowth of …

A Hiraide, K Hiroishi, J Eguchi, S Ishii, H Doi… - Cancer …, 2008 - Wiley Online Library
Dendritic cells (DC) are potent antigen‐presenting cells that elicit immune responses to
foreign antigens. We have previously demonstrated the synergistic effects of cytidine …

Dendritic cell maturation with CpG for tumor immunotherapy

M ARAB, M Motamedi, NE KHANSARI, Z GHEFLATI… - 2006 - sid.ir
Background: Bacterial DNA has immunostimulatory effects on different types of Immune cells
such as DENDRITIC CELL s (DCs). Application of DCs as a cellular adjuvant represents a …

Dendritic cell therapy with interferon-α synergistically suppresses outgrowth of established tumors in a murine colorectal cancer model

S Ishii, K Hiroishi, J Eguchi, A Hiraide, M Imawari - Gene therapy, 2006 - nature.com
Both dendritic cell (DC)-based immunotherapy and interferon (IFN)-α therapy have been
proved to have potent long-lasting antitumor effects. In anticipation of synergistic antitumor …

Enhanced dendritic cell maturation by TNF-α or cytidine-phosphate-guanosine DNA drives T cell activation in vitro and therapeutic anti-tumor immune responses in …

C Brunner, J Seiderer, A Schlamp… - The Journal of …, 2000 - journals.aai.org
Dendritic cells (DC) manipulated ex vivo can induce tumor immunity in experimental murine
tumor models. To improve DC-based tumor vaccination, we studied whether DC maturation …

Alteration of early dendritic cell activation by cancer cell lines predispose immunosuppression, which cannot be reversed by TLR4 stimulation

YY Kong, M Fuchsberger, M Plebanski… - Acta Biochimica et …, 2016 - academic.oup.com
Dendritic cells (DCs) have shown promise for use in cancer vaccine and cancer
immunotherapy studies. However, we demonstrate that cancer cell lines can negatively …

Plasmacytoid dendritic cells alter the antitumor activity of CpG-oligodeoxynucleotides in a mouse model of lung carcinoma

R Sorrentino, S Morello, A Luciano… - The Journal of …, 2010 - journals.aai.org
The effect of CpG-oligodeoxynucleotides (CpG) has been studied on a number of tumors.
Although CpG may facilitate tumor regression in mouse models of melanoma, its activity in …

Interleukin-4 and CpG oligonucleotide therapy suppresses the outgrowth of tumors by activating tumor-specific Th1-type immune responses

A Kajiwara, J Eguchi, S Ishii… - Oncology …, 2012 - spandidos-publications.com
Because IL-4 and CpG oligodeoxynucleotides (CpG-ODNs) are immune stimulants, we
evaluated the antitumor effects of IL-4 gene therapy and CpG-ODN treatment in a poorly …

[HTML][HTML] IL-10 in the microenvironment of HNSCC inhibits the CpG ODN-induced IFN-α secretion of pDCs

KL Bruchhage, S Heinrichs… - Oncology …, 2018 - spandidos-publications.com
It has been shown that head and neck squamous cell carcinoma (HNSCC) is infiltrated by
plasmacytoid dendritic cells (pDCs). The HNSCC TH2 biased microenvironment leads to …

Combined dendritic cell‐and CpG oligonucleotide‐based immune therapy cures large murine tumors that resist chemotherapy

K Heckelsmiller, S Beck, K Rall, B Sipos… - European journal of …, 2002 - Wiley Online Library
The use of dendritic cells (DC) loaded with tumor antigen is one of the most advanced
approaches in cancer immunotherapy. CpG motifs within microbial DNA detected by toll‐like …