The role of regulatory T cells in malignant glioma
The aggressive nature of gliomas is closely related to their capacity to evade the anti-
tumoral immune response. The mechanisms implicated in this phenomenon are only …
tumoral immune response. The mechanisms implicated in this phenomenon are only …
The role of regulatory T-cells in glioma immunology
YC Ooi, P Tran, N Ung, K Thill, A Trang… - Clinical neurology and …, 2014 - Elsevier
Despite recent advances in treatment, the prognosis for glioblastoma multiforme (GBM)
remains poor. The lack of response to treatment in GBM patients may be attributed to the …
remains poor. The lack of response to treatment in GBM patients may be attributed to the …
CD4+FoxP3+ regulatory T cells gradually accumulate in gliomas during tumor growth and efficiently suppress antiglioma immune responses in vivo
OM Grauer, S Nierkens, E Bennink… - … journal of cancer, 2007 - Wiley Online Library
The suppressive activity of regulatory T cells (Treg) has been implicated as an important
factor limiting immune mediated destruction of tumor cells. However, not much is known …
factor limiting immune mediated destruction of tumor cells. However, not much is known …
Prolongation of survival following depletion of CD4+ CD25+ regulatory T cells in mice with experimental brain tumors
A El Andaloussi, YU Han, MS Lesniak - Journal of neurosurgery, 2006 - thejns.org
Object Regulatory CD4+ CD25+ T cells have been shown to play an important role in the
regulation of the immune response. Whereas the presence of these cells has been …
regulation of the immune response. Whereas the presence of these cells has been …
[HTML][HTML] Depletion of regulatory T cells in a mouse experimental glioma model through anti-CD25 treatment results in the infiltration of non-immunosuppressive …
W Maes, T Verschuere, A Van Hoylandt… - Journal of Immunology …, 2013 - hindawi.com
The recruitment and activation of regulatory T cells (Tregs) in the micro-environment of
malignant brain tumors has detrimental effects on antitumoral immune responses. Hence …
malignant brain tumors has detrimental effects on antitumoral immune responses. Hence …
Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma
PE Fecci, DA Mitchell, JF Whitesides, W Xie… - Cancer research, 2006 - AACR
Immunosuppression is frequently associated with malignancy and is particularly severe in
patients with malignant glioma. Anergy and counterproductive shifts toward TH2 cytokine …
patients with malignant glioma. Anergy and counterproductive shifts toward TH2 cytokine …
Regulatory T cells actively infiltrate metastatic brain tumors
AQ Sugihara, CE Rolle… - … journal of oncology, 2009 - spandidos-publications.com
Abstract Regulatory T cells (CD4+ CD25+ FoxP3+, Treg) have been shown to play a major
role in suppression of the immune response to malignant gliomas. In this study, we …
role in suppression of the immune response to malignant gliomas. In this study, we …
Soluble factors secreted by glioblastoma cell lines facilitate recruitment, survival, and expansion of regulatory T cells: implications for immunotherapy
In patients with glioma, the tumor microenvironment can significantly impact pro-
inflammatory immune cell functions. However, the mechanisms by which this occurs are …
inflammatory immune cell functions. However, the mechanisms by which this occurs are …
The role of regulatory T cells and microglia in glioblastoma-associated immunosuppression
Cell-mediated suppression of anti-tumor immunity is multifactorial in patients with cancer,
and recent studies have focused on several distinct cellular agents that are associated with …
and recent studies have focused on several distinct cellular agents that are associated with …
Prognostic significance and mechanism of Treg infiltration in human brain tumors
JFM Jacobs, AJ Idema, KF Bol, JA Grotenhuis… - Journal of …, 2010 - Elsevier
Regulatory T cells (Tregs) accumulate in tumors and can contribute to the dismal immune
responses observed in these tumors. We reported that the percentage of tumor infiltrating …
responses observed in these tumors. We reported that the percentage of tumor infiltrating …
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