Adva-27a, a novel podophyllotoxin derivative found to be effective against multidrug resistant human cancer cells
A Merzouki, MD Buschmann, M Jean… - Anticancer …, 2012 - ar.iiarjournals.org
Background/Aim: Multidrug resistance poses a serious challenge in cancer therapy. To
address this problem, we designed and synthesized Adva-27a, a novel non-ester GEM …
address this problem, we designed and synthesized Adva-27a, a novel non-ester GEM …
[HTML][HTML] CIP-36, a novel topoisomerase II-targeting agent, induces the apoptosis of multidrug-resistant cancer cells in vitro
B Cao, H Chen, Y Gao, C Niu… - … Journal of Molecular …, 2015 - spandidos-publications.com
The need to overcome cancer multidrug resistance (MDR) has fueled considerable interest
in the development of novel synthetic antitumor agents with cytotoxicity against cancer cell …
in the development of novel synthetic antitumor agents with cytotoxicity against cancer cell …
A novel podophyllotoxin-derived compound GL331 is more potent than its congener VP-16 in killing refractory cancer cells
TS Huang, CC Lee, Y Chao, CH Shu, LT Chen… - Pharmaceutical …, 1999 - Springer
Purpose. GL331 is a new homolog of VP-16, and has demonstrated more efficacious anti-
cancer activity in both the in vitro and in vivo lymphoma systems. To extensively explore …
cancer activity in both the in vitro and in vivo lymphoma systems. To extensively explore …
Synthesis and evaluation of novel podophyllotoxin derivatives as potential antitumor agents
WH Cheng, B Cao, H Shang, C Niu, LM Zhang… - European Journal of …, 2014 - Elsevier
Cancer multidrug resistance (MDR) is a common cause of treatment failure in cancer
patients. Increased expression of permeability glycoprotein (P-gp), which is also known as …
patients. Increased expression of permeability glycoprotein (P-gp), which is also known as …
Design, synthesis and evaluation of the multidrug resistance-reversing activity of pyridine acid esters of podophyllotoxin in human leukemia cells
L Zhang, F Chen, Z Zhang, Y Chen, Y Lin… - Bioorganic & Medicinal …, 2016 - Elsevier
Multidrug resistance (MDR) is the main cause for chemotherapeutic failure in cancer
treatment. To overcome MDR, a serious of pyridine acid esters of podophyllotoxin was …
treatment. To overcome MDR, a serious of pyridine acid esters of podophyllotoxin was …
Novel isatin derivatives of podophyllotoxin: synthesis and cytotoxic evaluation against human leukaemia cancer cells as potent anti-MDR agents
L Zhang, F Chen, J Wang, Y Chen, Z Zhang, Y Lin… - RSC …, 2015 - pubs.rsc.org
Multidrug resistance (MDR) is a major cause of chemotherapy failure in cancer therapy. In
this study, a series of isatin derivatives of podophyllotoxin were synthesized and evaluated …
this study, a series of isatin derivatives of podophyllotoxin were synthesized and evaluated …
4β-[4′-(1-(Aryl) ureido) benzamide] podophyllotoxins as DNA topoisomerase I and IIα inhibitors and apoptosis inducing agents
A Kamal, P Suresh, MJ Ramaiah, TS Reddy… - Bioorganic & medicinal …, 2013 - Elsevier
Abstract A series of 4β-[4′-(1-(aryl) ureido) benzamide] podophyllotoxin congeners (11a–l)
were synthesized and evaluated for their cytotoxic activity against six human cancer cell …
were synthesized and evaluated for their cytotoxic activity against six human cancer cell …
Novel 4β-anilino-podophyllotoxin derivatives: design synthesis and biological evaluation as potent DNA-topoisomerase II poisons and anti-MDR agents
C Hu, D Xu, W Du, S Qian, L Wang, J Lou, Q He… - Molecular …, 2010 - pubs.rsc.org
A new series of 4β-anilino-podophyllotoxin analogs have been designed, synthesized and
evaluated their bioactivities as novel DNA-topoisomerase II poisons as well as P …
evaluated their bioactivities as novel DNA-topoisomerase II poisons as well as P …
[HTML][HTML] Design, synthesis, and biological evaluation of novel biotinylated podophyllotoxin derivatives as potential antitumor agents
CT Zi, YS Gao, L Yang, SY Feng, Y Huang… - Frontiers in …, 2019 - frontiersin.org
Podophyllotoxin has long been used as an active substance for cytotoxic activity. Fourteen
novel biotinylated podophyllotoxin derivatives were designed, synthesized, and evaluated …
novel biotinylated podophyllotoxin derivatives were designed, synthesized, and evaluated …
5k, a novel β-O-demethyl-epipodophyllotoxin analogue, inhibits the proliferation of cancer cells in vitro and in vivo via the induction of G2 arrest and apoptosis
D Xu, J Cao, S Qian, L Li, C Hu, Q Weng, J Lou… - Investigational new …, 2011 - Springer
Summary Etoposide (VP-16), a topoisomerase II (Topo II) inhibitor, has been widely used to
treat malignancies. Its clinical application, however, has been hindered by the rise of …
treat malignancies. Its clinical application, however, has been hindered by the rise of …