Is troponin I gene therapy effective for osteosarcoma treatment? Study on a human-like orthotopic rat model
A Dutour, H Rabinovich-Chable, C Kaletta… - Anticancer …, 2004 - ar.iiarjournals.org
Background: An anti-angiogenesis strategy has been widely recognized as a viable
approach to fight cancer and more and more anti-angiogenic factors are continually being …
approach to fight cancer and more and more anti-angiogenic factors are continually being …
Troponin I overexpression inhibits tumor growth, perfusion, and vascularization of morris hepatoma
K Schmidt, J Hoffend, A Altmann… - Journal of Nuclear …, 2006 - Soc Nuclear Med
Antiangiogenic gene transfer inhibiting growth of new blood vessels is a promising
approach in cancer therapy. Human troponin I (TnI) efficiently inhibits endothelial cell …
approach in cancer therapy. Human troponin I (TnI) efficiently inhibits endothelial cell …
Effect of recombinant human troponin C on the growth of human umbilical vein endothelial cells and mouse xenograft tumor
X Liu, H Zhou, X Deng - Chinese Journal of Tissue …, 2007 - pesquisa.bvsalud.org
BACKGROUND: Troponin I (Tn I) could inhibit the growth of vascular endothelial cells,
inhibit neovascularization, through which to inhibit the development and metastasis of solid …
inhibit neovascularization, through which to inhibit the development and metastasis of solid …
Expression of the human fast-twitch skeletal muscle troponin I cDNA in a human ovarian carcinoma suppresses tumor growth
GW Xiong, L Yang, YQ Wei, SL Wang, L Tian… - Science in China Series …, 2007 - Springer
To explore the efficiency and mechanism of ovarian carcinoma gene therapy with the human
fast-twitch skeletal muscle troponin I gene (Tnl-fast), Tnl-fast cDNA was transferred into …
fast-twitch skeletal muscle troponin I gene (Tnl-fast), Tnl-fast cDNA was transferred into …
Troponin I peptide (Glu94-Leu123), a cartilage-derived angiogenesis inhibitor: in vitro and in vivo effects on human endothelial cells and on pancreatic cancer
BE Kern, JH Balcom, BA Antoniu, AL Warshaw… - Journal of …, 2003 - Springer
Several inhibitors of angiogenesis have been identified in bovine and shark cartilage. One
of them is troponin I, which is the molecule responsible for the inhibition of the actomyosin …
of them is troponin I, which is the molecule responsible for the inhibition of the actomyosin …
Troponin I inhibits capillary endothelial cell proliferation by interaction with the cell's bFGF receptor
L Feldman, C Rouleau - Microvascular research, 2002 - Elsevier
Troponin I (TnI) is a novel cartilage-derived angiogenesis inhibitor, first demonstrated by
Moses et al.(1999, Proc. Natl. Acad. Sci. USA 2645–2650) to inhibit endothelial cell …
Moses et al.(1999, Proc. Natl. Acad. Sci. USA 2645–2650) to inhibit endothelial cell …
A polypeptide from shark troponin I can inhibit angiogenesis and tumor growth
Q Xie, S Yao, X Chen, L Xu, W Peng, L Zhang… - Molecular biology …, 2012 - Springer
The shark troponin I gene (TnI) was found for the first time in this study to inhibit endothelial
cell proliferation and angiogenesis. This shark TnI had 68.9% amino acid homology with …
cell proliferation and angiogenesis. This shark TnI had 68.9% amino acid homology with …
Identification and expression of troponin T, a new marker on the surface of cultured tumor endothelial cells by aptamer ligand
MN Ara, M Hyodo, N Ohga, K Akiyama, K Hida… - Cancer …, 2014 - Wiley Online Library
The identification of a specific biomarker involves the development of new clinical diagnostic
tools, and an in‐depth understanding of the disease at the molecular level. When new blood …
tools, and an in‐depth understanding of the disease at the molecular level. When new blood …
Oncostatin M Induces Bone Loss and Sensitizes Rat Osteosarcoma to the Antitumor Effect of Midostaurin In vivo
B Brounais, C Chipoy, K Mori, C Charrier… - Clinical Cancer …, 2008 - AACR
Purpose: In cultures, the cytokine oncostatin M (OSM) reduces the growth and induces
differentiation of osteoblasts and osteosarcoma cells into glial/osteocytic cells. Moreover …
differentiation of osteoblasts and osteosarcoma cells into glial/osteocytic cells. Moreover …
Improving the efficacy of osteosarcoma therapy: combining drugs that turn cancer cell 'don't eat me'signals off and 'eat me'signals on
The long‐term survival of osteosarcoma patients with metastatic or recurrent disease
remains dismal, and new therapeutic options are urgently needed. The purpose of our study …
remains dismal, and new therapeutic options are urgently needed. The purpose of our study …