Is troponin I gene therapy effective for osteosarcoma treatment? Study on a human-like orthotopic rat model

A Dutour, H Rabinovich-Chable, C Kaletta… - Anticancer …, 2004 - ar.iiarjournals.org
Background: An anti-angiogenesis strategy has been widely recognized as a viable
approach to fight cancer and more and more anti-angiogenic factors are continually being …

Troponin I overexpression inhibits tumor growth, perfusion, and vascularization of morris hepatoma

K Schmidt, J Hoffend, A Altmann… - Journal of Nuclear …, 2006 - Soc Nuclear Med
Antiangiogenic gene transfer inhibiting growth of new blood vessels is a promising
approach in cancer therapy. Human troponin I (TnI) efficiently inhibits endothelial cell …

Effect of recombinant human troponin C on the growth of human umbilical vein endothelial cells and mouse xenograft tumor

X Liu, H Zhou, X Deng - Chinese Journal of Tissue …, 2007 - pesquisa.bvsalud.org
BACKGROUND: Troponin I (Tn I) could inhibit the growth of vascular endothelial cells,
inhibit neovascularization, through which to inhibit the development and metastasis of solid …

Expression of the human fast-twitch skeletal muscle troponin I cDNA in a human ovarian carcinoma suppresses tumor growth

GW Xiong, L Yang, YQ Wei, SL Wang, L Tian… - Science in China Series …, 2007 - Springer
To explore the efficiency and mechanism of ovarian carcinoma gene therapy with the human
fast-twitch skeletal muscle troponin I gene (Tnl-fast), Tnl-fast cDNA was transferred into …

Troponin I peptide (Glu94-Leu123), a cartilage-derived angiogenesis inhibitor: in vitro and in vivo effects on human endothelial cells and on pancreatic cancer

BE Kern, JH Balcom, BA Antoniu, AL Warshaw… - Journal of …, 2003 - Springer
Several inhibitors of angiogenesis have been identified in bovine and shark cartilage. One
of them is troponin I, which is the molecule responsible for the inhibition of the actomyosin …

Troponin I inhibits capillary endothelial cell proliferation by interaction with the cell's bFGF receptor

L Feldman, C Rouleau - Microvascular research, 2002 - Elsevier
Troponin I (TnI) is a novel cartilage-derived angiogenesis inhibitor, first demonstrated by
Moses et al.(1999, Proc. Natl. Acad. Sci. USA 2645–2650) to inhibit endothelial cell …

A polypeptide from shark troponin I can inhibit angiogenesis and tumor growth

Q Xie, S Yao, X Chen, L Xu, W Peng, L Zhang… - Molecular biology …, 2012 - Springer
The shark troponin I gene (TnI) was found for the first time in this study to inhibit endothelial
cell proliferation and angiogenesis. This shark TnI had 68.9% amino acid homology with …

Identification and expression of troponin T, a new marker on the surface of cultured tumor endothelial cells by aptamer ligand

MN Ara, M Hyodo, N Ohga, K Akiyama, K Hida… - Cancer …, 2014 - Wiley Online Library
The identification of a specific biomarker involves the development of new clinical diagnostic
tools, and an in‐depth understanding of the disease at the molecular level. When new blood …

Oncostatin M Induces Bone Loss and Sensitizes Rat Osteosarcoma to the Antitumor Effect of Midostaurin In vivo

B Brounais, C Chipoy, K Mori, C Charrier… - Clinical Cancer …, 2008 - AACR
Purpose: In cultures, the cytokine oncostatin M (OSM) reduces the growth and induces
differentiation of osteoblasts and osteosarcoma cells into glial/osteocytic cells. Moreover …

Improving the efficacy of osteosarcoma therapy: combining drugs that turn cancer cell 'don't eat me'signals off and 'eat me'signals on

S Mohanty, M Aghighi, K Yerneni… - Molecular …, 2019 - Wiley Online Library
The long‐term survival of osteosarcoma patients with metastatic or recurrent disease
remains dismal, and new therapeutic options are urgently needed. The purpose of our study …