[HTML][HTML] An in-silico approach leads to explore six genes as a molecular signatures of lung adenocarcinoma
MA Abdel-Maksoud, F Hassan, U Mubarik… - American Journal of …, 2023 - ncbi.nlm.nih.gov
Due to heterogenetic-specific nature of the available biomarkers, the incidence of lung
adenocarcinoma (LUAD) is on the rise worldwide. Previously reported LUAD-related hub …
adenocarcinoma (LUAD) is on the rise worldwide. Previously reported LUAD-related hub …
[HTML][HTML] PDZ binding kinase/T-LAK cell-derived protein kinase plays an oncogenic role and promotes immune escape in human tumors
T Feng, Y Zhang, S Ling, C Xu, Y Lyu, T Lu, X Liu… - Journal of …, 2021 - hindawi.com
Background. PDZ binding kinase (PBK)/T-LAK cell-derived protein kinase (TOPK) is an
important mitotic kinase that promotes tumor progression in some cancers. However, the …
important mitotic kinase that promotes tumor progression in some cancers. However, the …
[HTML][HTML] Targeting EFNA1 suppresses tumor progression via the cMYC-modulated cell cycle and autophagy in esophageal squamous cell carcinoma
H Jiang, S Wang, Y Liu, C Zheng, L Chen, K Zheng… - Discover Oncology, 2023 - Springer
Purpose Esophageal squamous cell carcinoma (ESCC) remains one of the most common
causes of cancer death due to the lack of effective therapeutic options. New targets and the …
causes of cancer death due to the lack of effective therapeutic options. New targets and the …
Centromere protein E as a novel biomarker and potential therapeutic target for retinoblastoma
K Shi, X Zhu, J Wu, Y Chen, J Zhang, X Sun - Bioengineered, 2021 - Taylor & Francis
Retinoblastoma is the most common intraocular malignancy during childhood. Currently,
there is no effective treatment for metastatic retinoblastoma. We investigated potential …
there is no effective treatment for metastatic retinoblastoma. We investigated potential …
PDZ‐binding kinase inhibitor OTS514 suppresses the proliferation of oral squamous carcinoma cells
M Kato, A Ota, T Ono, S Karnan, T Hyodo… - Oral …, 2024 - Wiley Online Library
Objective PDZ‐binding kinase (PBK) has been reported as a poor prognostic factor and is a
promising molecular target for anticancer therapeutics. Here, we aimed to investigate the …
promising molecular target for anticancer therapeutics. Here, we aimed to investigate the …
[HTML][HTML] Omics-and pharmacogenomic evidence for the prognostic, regulatory, and immune-related roles of PBK in a pan-cancer cohort
Y Liu, J Xiang, G Peng, C Shen - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
PDZ-binding kinase (PBK) is known to regulate tumor progression in some cancer types.
However, its relationship to immune cell infiltration and prognosis in different cancers is …
However, its relationship to immune cell infiltration and prognosis in different cancers is …
[HTML][HTML] A robust six-gene prognostic signature based on two prognostic subtypes constructed by chromatin regulators is correlated with immunological features and …
Q Chen, H Zhao, J Hu - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
Accumulating evidence has demonstrated that chromatin regulators (CRs) regulate immune
cell infiltration and are correlated with prognoses of patients in some cancers. However, the …
cell infiltration and are correlated with prognoses of patients in some cancers. However, the …
[HTML][HTML] PBK/TOPK is a favorable prognostic biomarker correlated with antitumor immunity in colon cancers
Immune checkpoint inhibitor therapy has proven efficacy in a subset of colon cancer patients
featuring a deficient DNA mismatch repair system or a high microsatellite instability profile …
featuring a deficient DNA mismatch repair system or a high microsatellite instability profile …