Inflammasomes are macromolecular platforms formed in response to damage-associated
molecular patterns (DAMPs) and pathogen-associated molecular patterns, whose formation …

The NLRP3 inflammasome is an intracellular sensor and an essential component of the
innate immune system involved in danger recognition. An important hallmark of …

Hepatectomy is currently considered the most effective option for treating patients with early
and intermediate hepatocellular carcinoma (HCC). Unfortunately, the postoperative …

Abstract Tranilast (TRN) or (N-3, 4-dimethoxy cinnamoyl]-anthranilic acid) is an analog of a
tryptophan metabolite and is identified mainly as an anti-allergic agent with limited side …

Tranilast (N-3, 4-dimethoxycinnamoyl anthranilic acid) is an orally administered drug with
antiallergic properties and approved in Japan and the Republic of Korea for the treatment of …

Epithelial‑mesenchymal transition (EMT) promotes primary tumor progression toward a
metastatic state. The role of tumor‐associated macrophages (TAMs) in inducing EMT in lung …

Introduction: Prostate cancer is the second-leading cause of cancer death in men. Sinularin
is a soft coralsderived natural compound that has anticancer activity in many cancer cells …

Wnt signaling is a critical determinant of cell lineage development. This study used Wnt dose-
dependent induction programs to gain insights into molecular regulation of stem cell …

Lung cancer (LC) is the primary reason for cancer-associated fatalities globally. Due to both
tumor-suppressing and tumor-promoting activities, the TGF-β family of growth factors is …

Small-cell lung cancer (SCLC), which accounts for about 15% of all lung cancers,
progresses more rapidly than other histologic types and is rarely detected at an operable …