[HTML][HTML] The Role of Peroxiredoxins in Cancer Development

P Thapa, H Jiang, N Ding, Y Hao, A Alshahrani, Q Wei - Biology, 2023 - mdpi.com
Simple Summary Reactive oxygen species (ROS) are unstable derivatives of oxygen that
are generated naturally as products or biproducts of biological reactions. ROS, such as …

[HTML][HTML] Effects of antioxidant gene overexpression on stress resistance and malignization in vitro and in vivo: a review

MM Tavleeva, ES Belykh, AV Rybak, EE Rasova… - Antioxidants, 2022 - mdpi.com
Reactive oxygen species (ROS) are normal products of a number of biochemical reactions
and are important signaling molecules. However, at the same time, they are toxic to cells …

[HTML][HTML] A CRISPR screen identifies redox vulnerabilities for KEAP1/NRF2 mutant non-small cell lung cancer

C Jiang, NP Ward, N Prieto-Farigua, YP Kang… - Redox Biology, 2022 - Elsevier
The redox regulator NRF2 is hyperactivated in a large percentage of non-small cell lung
cancer (NSCLC) cases, which is associated with chemotherapy and radiation resistance. To …

Shikonin-induced apoptosis of colon cancer cells is reduced by peroxiredoxin V expression

N Chandimali, HN Sun, LZ Kong, X Zhen… - Anticancer …, 2019 - ar.iiarjournals.org
Background/Aim: Colon cancer is the second most common deadliest malignancy in the
world and better understanding of its underlying mechanisms is needed to improve clinical …

[HTML][HTML] Knockdown of Peroxiredoxin V increased the cytotoxicity of non-thermal plasma-treated culture medium to A549 cells

HN Sun, XY Guo, DP Xie, XM Wang, CX Ren… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Administration of non-thermal plasma therapy via the use of plasma-activated medium
(PAM) might be a novel strategy for cancer treatment, as it induces apoptosis by increasing …

Anti-tumor properties of Picrasma quassioides extracts in H-RasG12V liver cancer are mediated through ROS-dependent mitochondrial dysfunction

DP Xie, YX Gong, YH Jin, CX Ren, Y Liu… - Anticancer …, 2020 - ar.iiarjournals.org
Background: Picrasma quassioides (PQ) is a traditional Asian herbal medicine with anti-
tumor properties that can inhibit the viability of HepG2 liver cancer cells. H-Ras is often …

Screening a redox library identifies the anti-tumor drug Hinokitiol for treating intrahepatic cholangiocarcinoma

P Bai, C Ge, H Yang, H Chen, L Wan… - Frontiers in …, 2022 - research.rug.nl
Aims: Intrahepatic cholangiocarcinoma (ICC) is a highly malignant and heterogeneous
cancer with a poor prognosis. At present, there is no optimal treatment except for surgical …

Assessment of potential prognostic value of peroxiredoxin 1 in oral squamous cell carcinoma

Y Shen, H Xu, L Li, Y Lu, M Zhang… - Cancer Management …, 2021 - Taylor & Francis
Purpose The role of the peroxiredoxin (PRDX) family in oral squamous cell carcinoma
(OSCC) remains unclear. This study aimed to investigate the expression of PRDXs and their …

Peroxiredoxin V Silencing Elevates Susceptibility to Doxorubicin-induced Cell Apoptosis via ROS-dependent Mitochondrial Dysfunction in AGS Gastric Cancer Cells

YZ Jin, YX Gong, Y Liu, DP Xie, CX Ren… - Anticancer …, 2021 - ar.iiarjournals.org
Background/Aim: Peroxiredoxin V (Prx V) plays crucial roles in cellular apoptosis and
proliferation in various cancer cells by regulating the cellular reactive oxygen species (ROS) …

[HTML][HTML] Peroxiredoxin 5 protects HepG2 cells from ethyl β-carboline-3-carboxylate-induced cell death via ROS-dependent MAPK signalling pathways

DP Xie, YX Gong, J Lee, EM Jeong, CX Ren… - Journal of …, 2022 - ncbi.nlm.nih.gov
Abstract Peroxiredoxin 5 (PRDX5) is the member of Prxs family, widely reported to be
involved in various types of cell death. We previously found that PRDX5 knockdown …