Iodine-resistant cancers account for the vast majority of thyroid related mortality and, until
recently, there were limited therapeutic options. However, over the last decade our …

Valproic acid, a branching short chain fatty acid, is a popular drug to treat epilepsy and acts
as a mood-stabilizing drug. The obstruction of ion channels and Gamma Amino Butyrate …

Background/Aim: There is a strong association between malignancy and histone
deacetylases (HDACs). Histone deacetylase inhibitors (HDACIs) are now being tested as …

Thyroid cancer is the most common malignancy of the endocrine system with a steadily
rising incidence. The term “thyroid cancer” encompasses a spectrum of subtypes, namely …

Colorectal cancer (CRC) comprises a heterogeneous group of gastrointestinal tract tumors.
It is a multifactorial disease, and a plethora of distinct factors are involved in its pathogenesis …

Control of neovascularization with small molecules is a promising tactics. Here, we tested
the roles of sodium butyrate (NaBu) on the neovascularization and primary explained its …

Simple Summary Merging evidence has indicated that dedifferentiation is the main concern
associated with radioactive iodine (RAI) refractoriness in patients with papillary thyroid …

Background/Aim: Papillary Thyroid Cancer (PTC) is the most common type of endocrine
malignancy. Although PTC has an excellent prognosis, the recurrent or metastatic disease …

Histone deacetylase inhibitor (HDACi) is a drug mainly used to treat hematological tumors
and breast cancer, but its inhibitory effect on breast cancer falls short of expectations. Grape …

Anaplastic thyroid cancer (ATC) is one of the most lethal human malignancies, and it is
rapidly falling without any effective therapeutic options. Although radical surgery …