Peptide sequence-dominated enzyme-responsive nanoplatform for anticancer drug delivery

Y Li, L Du, C Wu, B Yu, H Zhang… - Current Topics in …, 2019 - ingentaconnect.com
Enzymatic dysregulation in tumor and intracellular microenvironments has made this
property a tremendously promising responsive element for efficient diagnostics, carrier …

A comparative analysis of recombinant Fab and full‐length antibody production in Chinese hamster ovary cells

H Hussain, T Patel, AMS Ozanne, D Vito… - Biotechnology and …, 2021 - Wiley Online Library
Monoclonal antibodies are the leading class of biopharmaceuticals in terms of numbers
approved for therapeutic purposes. Antigen‐binding fragments (Fab) are also used as …

Functional diversification of hybridoma-produced antibodies by CRISPR/HDR genomic engineering

JMS van der Schoot, FL Fennemann, M Valente… - Science …, 2019 - science.org
Hybridoma technology is instrumental for the development of novel antibody therapeutics
and diagnostics. Recent preclinical and clinical studies highlight the importance of antibody …

[HTML][HTML] BODIPY Dye Derivative for Irreversible Fluorescent Labeling of Eukaryotic Cells and Their Simultaneous Cytometric Analysis

AY Frolova, SV Kutyakov, VI Martynov, SM Deyev… - Acta …, 2023 - ncbi.nlm.nih.gov
In this work, we synthesized a green fluorescent dye derivative, 1, 3, 5, 7-tetramethyl-
BODIPY, with a heptyl substituent at the 8-position. The obtained highly hydrophobic …

BODIPY dye derivative for irreversible fluorescent labeling of various eukaryotic cell cultures and their subsequent simultaneous cytometric analysis

AY Frolova, SV Kutyakov, VI Martynov, SM Deyev… - Acta …, 2023 - actanaturae.ru
In the present work, we synthesized a green fluorescent dye derivative 1, 3, 5, 7-tetramethyl-
BODIPY with a hexyl substituent at the meso-position. The obtained highly hydrophobic …

Generation and testing of engineered multimeric Fabs of trastuzumab

F Selis, A Sandomenico, M Cantile, R Sanna… - International Journal of …, 2020 - Elsevier
Recombinant antibodies fragments in several new formats are routinely investigated and
used in diagnostic and therapeutic applications as anti-cancers molecules. New antibody …