[HTML][HTML] Interactions of analgesics with cisplatin: Modulation of anticancer efficacy and potential organ toxicity

A El-Sheikh, Z Khired - Medicina, 2021 - mdpi.com
Cisplatin (CDDP), one of the most eminent cancer chemotherapeutic agents, has been
successfully used to treat more than half of all known cancers worldwide. Despite its …

The role of opioids and their receptors in urological malignancy: a review

PM Lec, AT Lenis, V Golla, W Brisbane… - The Journal of …, 2020 - auajournals.org
Purpose: We reviewed the literature surrounding the role of opioids and their receptors in
urological malignancy. Recent studies have suggested clinically significant effects of …

d,l-Methadone does not improve radio- and chemotherapy in glioblastoma in vitro

H Oppermann, M Matusova, A Glasow… - Cancer Chemotherapy …, 2019 - Springer
Purpose Glioblastoma (GBM) is the most common malignant tumor of the central nervous
system. Median survival of glioblastoma patients under standard therapy including …

[HTML][HTML] Methadone Requires the Co-Activation of μ-Opioid and Toll-Like-4 Receptors to Produce Extracellular DNA Traps in Bone-Marrow-Derived Mast Cells

FL Martínez-Cuevas, SL Cruz… - International Journal of …, 2024 - mdpi.com
Methadone is an effective and long-lasting analgesic drug that is also used in medication-
assisted treatment for people with opioid use disorders. Although there is evidence that …

[HTML][HTML] Discussion on the benefits of different treatment strategies in elderly and non-elderly patients with appendix MiNEN: a retrospective study based on SEER …

X Xing, Y Zhang, L Wang, Y Wang, Z Zhang… - International Journal of …, 2023 - Springer
Purpose To investigate the benefits of surgery alone and postoperative chemotherapy in
elderly and non-elderly patients with appendiceal mixed neuroendocrine non …

The role of opioids in cancer progression

MF Ramirez, A Gorur, JP Cata - International anesthesiology …, 2020 - journals.lww.com
Cancer is the second most common cause of death in the United States. The vast majority of
cancer-related deaths occur due to metastatic disease, which may be the result of direct …

[HTML][HTML] Methadone-mediated sensitization of glioblastoma cells is drug and cell line dependent

B Haas, J Ciftcioglu, S Jermar, S Weickhardt… - Journal of Cancer …, 2021 - Springer
Purpose d, l-methadone (MET), an analgesic drug used for pain treatment and opiate
addiction, has achieved attention from oncologists and social media as possible …

Methadone enhances the effectiveness of 5‐aminolevulinic acid‐based photodynamic therapy for squamous cell carcinoma and glioblastoma in vitro

L Shi, A Buchner, H Pohla, T Pongratz… - Journal of …, 2019 - Wiley Online Library
Although having shown promising clinical outcomes, the effectiveness of 5‐aminolevulinic
acid‐based photodynamic therapy (ALA‐PDT) for squamous cell carcinoma (SCC) and …

[HTML][HTML] Against repurposing methadone for glioblastoma therapy

T Vatter, L Klumpp, K Ganser, N Stransky, D Zips… - Biomolecules, 2020 - mdpi.com
Methadone, which is used as maintenance medication for outpatient treatment of opioid
dependence or as an analgesic drug, has been suggested by preclinical in vitro and mouse …

DL-methadone as an enhancer of chemotherapeutic drugs in head and neck cancer cell lines

V Landgraf, M Griessmann, J Roller… - Anticancer …, 2019 - ar.iiarjournals.org
Background/Aim: The aim of this study was to analyze the effect of DL-methadone on
enhancing the action of the chemotherapeutic drugs cisplatin, doxorubicin, 5-fluoruracil (5 …