Angiogenesis as a potential treatment strategy for rheumatoid arthritis

Y Wang, H Wu, R Deng - European Journal of Pharmacology, 2021 - Elsevier
Angiogenesis is an early and key event in the pathogenesis of rheumatoid arthritis (RA) and
is crucial for the proliferation of synovial tissue and the formation of pannus. This process is …

Therapeutic implication of vascular endothelial growth factor receptor-1 (VEGFR-1) targeting in cancer cells and tumor microenvironment by competitive and non …

PM Lacal, G Graziani - Pharmacological research, 2018 - Elsevier
The vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase receptor
for VEGF-A, VEGF-B, and placental growth factor (PlGF) ligands that is expressed in …

[HTML][HTML] Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumor drug accumulation and limiting …

N Ingram, LE McVeigh, RH Abou-Saleh, J Maynard… - Theranostics, 2020 - ncbi.nlm.nih.gov
Most cancer patients receive chemotherapy at some stage of their treatment which makes
improving the efficacy of cytotoxic drugs an ongoing and important goal. Despite large …

[HTML][HTML] Next-generation digital histopathology of the tumor microenvironment

F Mungenast, A Fernando, R Nica, B Boghiu, B Lungu… - Genes, 2021 - mdpi.com
Progress in cancer research is substantially dependent on innovative technologies that
permit a concerted analysis of the tumor microenvironment and the cellular phenotypes …

[HTML][HTML] Propofol attenuated TNF-α-modulated occludin expression by inhibiting Hif-1α/VEGF/VEGFR-2/ERK signaling pathway in hCMEC/D3 cells

Y Zhang, X Ding, C Miao, J Chen - BMC anesthesiology, 2019 - Springer
Background The levels of tight junction proteins (TJs), especially occludin, correlate with
blood-brain barrier (BBB) disruption caused by inflammation in central nervous system …

Fruquintinib: a novel antivascular endothelial growth factor receptor tyrosine kinase inhibitor for the treatment of metastatic colorectal cancer

Y Zhang, JY Zou, Z Wang, Y Wang - Cancer Management and …, 2019 - Taylor & Francis
Angiogenesis plays a critical role in the neoplastic growth, progression, and metastasis of
colorectal cancer (CRC) in a process regulated by vascular endothelial growth factor (VEGF) …

The emerging era of personalized medicine in advanced colorectal cancer

CWK Wu, M Reid, S Leedham… - … of gastroenterology and …, 2022 - Wiley Online Library
Colorectal cancer (CRC) is a genetically heterogeneous disease with its pathogenesis often
driven by varying genetic or epigenetic alterations. This has led to a substantial number of …

[HTML][HTML] Differential expression of VEGFR2 protein in HER2 positive primary human breast cancer: potential relevance to anti-angiogenic therapies

A Nasir, TR Holzer, M Chen, MZ Man… - Cancer cell international, 2017 - Springer
Background Clinically relevant predictive biomarkers to tailor anti-angiogenic therapies to
breast cancer (BRC) patient subpopulations are an unmet need. Methods We analyzed …

[HTML][HTML] Prognostic significance and relationship of SMAD3 phospho-isoforms and VEGFR-1 in gastric cancer: A clinicopathological study

SL Lv, P Guo, JR Zou, RS Chen, LY Luo… - World Journal of …, 2024 - ncbi.nlm.nih.gov
BACKGROUND The TGF-β/SMAD3 and VEGFR-1 signaling pathways play important roles
in gastric cancer metastasis. SMAD3 phosphorylation is a crucial prognostic marker in …

Profiling of vascular endothelial growth factor receptor heterogeneity identifies protein expression-defined subclasses of human non-small cell lung carcinoma

TR Holzer, AD Fulford, LON Reising… - Anticancer …, 2016 - ar.iiarjournals.org
Background: the vascular endothelial growth factor (VEGF) pathway plays a prominent role
in the growth and progression of human cancer, including non-small cell lung carcinoma …