Lung cancer is one of the most common cancers and has a high mortality rate. Due to its
high incidence, the clinical management of the disease remains a major challenge. Several …

Simple Summary Anoikis is a programmed cell death process resulting from the loss of
interaction between cells and the extracellular matrix. Therefore, it is necessary to overcome …

The development of effective treatments for cancers requires investigations for a more
detailed and comprehensive understanding of the basic cellular mechanisms involved in …

Despite the huge investment into research and the significant effort and advances made in
the search for new anticancer drugs in recent decades, cancer cure and treatment continue …

Immune checkpoint antibodies in cancer treatment are receptor-ligand pairs that modulate
cancer immunity. PD-1/PD-L1 pathway has emerged as one of the major targets in cancer …

Natural products (NPs) are useful sources of bioactive compounds and play important roles
in the development and discovery of new drugs for diverse human diseases. Most natural …

A dysregulation of the cell-death mechanism contributes to poor prognosis in lung cancer.
New potent chemotherapeutic agents targeting apoptosis-deregulating molecules have …

Cancer stem cells (CSCs) drive aggressiveness and metastasis by utilizing stem cell-related
signals. In this study, 5-O-(N-Boc-l-alanine)-renieramycin T (OBA-RT) was demonstrated to …

As lung cancer is the most common malignancy worldwide and high mortalities are the
result of metastasis, novel information surpassing the treatment strategies and therapeutic …

Marine natural products are known for their diverse chemical structures and extensive
bioactivities. Renieramycins, the member of tetrahydroisoquinoline family of marine natural …