Small molecules regulating reactive oxygen species homeostasis for cancer therapy

J Zhang, D Duan, ZL Song, T Liu… - Medicinal Research …, 2021 - Wiley Online Library
Elevated intracellular reactive oxygen species (ROS) and antioxidant defense systems have
been recognized as one of the hallmarks of cancer cells. Compared with normal cells …

A role of gallic acid in oxidative damage diseases: A comprehensive review

J Gao, J Hu, D Hu, X Yang - Natural Product …, 2019 - journals.sagepub.com
Gallic acid is a trihydroxybenzoic acid of plant metabolites widely spread throughout the
plant kingdom. It has characteristics of the strong antioxidant and free radical scavenging …

Gallic acid and gallates in human health and disease: do mitochondria hold the key to success?

RY Kosuru, A Roy, SK Das… - Molecular nutrition & food …, 2018 - Wiley Online Library
Gallic acid and gallate esters are widely used as dietary supplements or additives with
clinical significances. Over the last few decades, a large number of publications have been …

Gallic acid: A dietary polyphenol that exhibits anti-neoplastic activities by modulating multiple oncogenic targets

HS Tuli, H Mistry, G Kaur, D Aggarwal… - Anti-Cancer Agents …, 2022 - ingentaconnect.com
Phytochemicals are being used for thousands of years to prevent dreadful malignancy. Side
effects of existing allopathic treatment have also initiated intense research in the field of …

Photosensitized methyl paraben induces apoptosis via caspase dependent pathway under ambient UVB exposure in human skin cells

D Dubey, D Chopra, J Singh, AK Srivastav… - Food and chemical …, 2017 - Elsevier
Methyl paraben (MP), is a widely used preservative in pharmaceutical, food and cosmetic
products. Its molecular mechanism under ambient ultraviolet radiation is not well …

[HTML][HTML] Tunicamycin Induces Hepatic Stellate Cell Apoptosis Through Calpain-2/Ca2 +-Dependent Endoplasmic Reticulum Stress Pathway

H Liu, L Dai, M Wang, F Feng, Y Xiao - Frontiers in Cell and …, 2021 - frontiersin.org
It has been reported that calpain/caspase-mediated apoptosis induced by endoplasmic
reticulum stress (ERS) in hepatic stellate cells (HSCs) by previous studies. At present, the …

[HTML][HTML] Gallnuts: a potential treasure in anticancer drug discovery

J Gao, X Yang, W Yin, M Li - Evidence-Based Complementary and …, 2018 - hindawi.com
Introduction. In the discovery of more potent and selective anticancer drugs, the research
continually expands and explores new bioactive metabolites coming from different natural …

[HTML][HTML] Could dantrolene be explored as a repurposed drug to treat COVID-19 patients by restoring intracellular calcium homeostasis?

B Jiang, S Liang, G Liang, H Wei - European review for medical …, 2020 - ncbi.nlm.nih.gov
Dantrolene, an FDA approved drug to treat malignant hyperthermia and muscle spasm, has
been demonstrated to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

[HTML][HTML] Mapping pharmacological network of multi-targeting litchi ingredients in cancer therapeutics

S Cao, Y Han, Z Su - Frontiers in Pharmacology, 2020 - frontiersin.org
Considerable pharmacological studies have demonstrated that the extracts and ingredients
from different parts (seeds, peels, pulps, and flowers) of Litchi exhibited anticancer effects by …

Galangin induces p53-independent S-phase arrest and apoptosis in human nasopharyngeal carcinoma cells through inhibiting PI3K–AKT signaling pathway

CC Lee, ML Lin, M Meng, SS Chen - Anticancer Research, 2018 - ar.iiarjournals.org
Background/Aim: Anti-cancer activity of 3, 5, 7-trihydroxyflavone (galangin) has been
documented in a variety of cancer types; however, its effect on human nasopharyngeal …