Reactive oxygen species (ROS) are a group of short-lived, highly reactive, oxygen-
containing molecules that can induce DNA damage and affect the DNA damage response …

The development of colorectal cancer is a complex and multistep process mediated by a
variety of factors including the dysregulation of genetic and epigenetic under the influence of …

Double-strand breaks are among the first procedures taking place in cancer formation and
progression as a result of endogenic and exogenic factors. The histone variant H2AX …

Epigenetic regulations play a crucial role in the expression of various genes that are
important in the normal cell function. Any alteration in these epigenetic mechanisms can …

Traditionally the stratification of many cancers involves combining tumour and
clinicopathological features (eg, patient age; tumour size, grade, receptor status and …

Global alterations in epigenetic landscape are now recognized as a hallmark of cancer.
Epigenetic mechanisms such as DNA methylation, histone modifications, nucleosome …

Abstract H3K9 methyltransferase (G9a) and its relevant molecule GLP are the SET domain
proteins that specifically add mono, di and trimethyl groups on to the histone H3K9, which …

Thanks to the advancement in science and technology and a significant number of cancer
research programs being carried out throughout the world, the prevention, prognosis and …

Histone modification is aberrantly regulated in cancer and generates an unbalanced state of
gene transcription. VprBP, a recently identified kinase, phosphorylates histone H2A on …

At the cellular level, cancer is the disease of both the genome and the epigenome, and the
interplay between genetic mutations and epigenetic states may occur at the level of …