The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target
Targeted drugs have changed cancer treatment but are often ineffective in the long term
against solid tumours, largely because of the activation of heterogeneous oncogenic …
against solid tumours, largely because of the activation of heterogeneous oncogenic …
Biological function of Pin1 in vivo and its inhibitors for preclinical study: Early development, current strategies, and future directions
S He, L Li, R Jin, X Lu - Journal of Medicinal Chemistry, 2023 - ACS Publications
Peptidyl-prolyl cis/trans isomerase family (PPIase) is structurally divided into three
subfamilies, cyclophilins (Cyps), FK506-binding proteins (FKBPs), and parvulins. Pin1 …
subfamilies, cyclophilins (Cyps), FK506-binding proteins (FKBPs), and parvulins. Pin1 …
[HTML][HTML] SGK1 in human cancer: emerging roles and mechanisms
Y Sang, P Kong, S Zhang, L Zhang, Y Cao… - Frontiers in …, 2021 - frontiersin.org
Serum and glucocorticoid-induced protein kinase 1 (SGK1) is a member of the “AGC”
subfamily of protein kinases, which shares structural and functional similarities with the AKT …
subfamily of protein kinases, which shares structural and functional similarities with the AKT …
[HTML][HTML] Function of PIN1 in cancer development and its inhibitors as cancer therapeutics
JH Yu, CY Im, SH Min - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Peptidyl-prolyl isomerase (PIN1) specifically binds and isomerizes the phosphorylated
serine/threonine–proline (pSer/Thr–Pro) motif, which results in the alteration of protein …
serine/threonine–proline (pSer/Thr–Pro) motif, which results in the alteration of protein …
Next-generation sequencing
M Le Gallo, F Lozy, DW Bell - Molecular Genetics of Endometrial …, 2017 - Springer
Endometrial cancers are the most frequently diagnosed gynecological malignancy and were
expected to be the seventh leading cause of cancer death among American women in 2015 …
expected to be the seventh leading cause of cancer death among American women in 2015 …
Pin1 inhibition potently suppresses gastric cancer growth and blocks PI3K/AKT and Wnt/β‐catenin oncogenic pathways
Z Zhang, W Yu, M Zheng, X Liao, J Wang… - Molecular …, 2019 - Wiley Online Library
Gastric cancer is the second leading cause of cancer‐related mortality and the fourth most
common cancer globally. High intratumor heterogeneity of advanced gastric cancer poses …
common cancer globally. High intratumor heterogeneity of advanced gastric cancer poses …
Regulation of eukaryotic protein kinases by Pin1, a peptidyl-prolyl isomerase
XR Chen, TI Igumenova - Advances in biological regulation, 2023 - Elsevier
The peptidyl-prolyl isomerase Pin1 cooperates with proline-directed kinases and
phosphatases to regulate multiple oncogenic pathways. Pin1 specifically recognizes …
phosphatases to regulate multiple oncogenic pathways. Pin1 specifically recognizes …
[HTML][HTML] Perfluorooctanoic acid induces migration and invasion and inhibits apoptosis through the PI3K/AKT signaling pathway in human rhabdomyosarcoma cells
Q Zhang, J Wang, C Chen, Y Kong… - Oncology …, 2019 - spandidos-publications.com
The present study aimed to investigate the effects of perfluorooctanoic acid (PFOA) on tumor
cell migration, invasion and apoptosis by activation of the PI3K/AKT signaling pathway in …
cell migration, invasion and apoptosis by activation of the PI3K/AKT signaling pathway in …
Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 as a molecular target in breast cancer: a therapeutic perspective of gynecological cancer
G Kim, PY Bhattarai, HS Choi - Archives of pharmacal research, 2019 - Springer
Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (PIN1) induces conformational and
functional changes to numerous key signaling molecules following proline-directed …
functional changes to numerous key signaling molecules following proline-directed …
[HTML][HTML] Predictive value of Pin1 in cervical low-grade squamous intraepithelial lesions and inhibition of Pin1 exerts potent anticancer activity against human cervical …
YT Guo, Y Lu, YY Jia, HN Qu, D Qi, XQ Wang… - Aging and …, 2020 - ncbi.nlm.nih.gov
Many oncogenes are involved in the progression from low-grade squamous intraepithelial
lesions (LSILs) to high-grade squamous intraepithelial lesions (HSILs); which greatly …
lesions (LSILs) to high-grade squamous intraepithelial lesions (HSILs); which greatly …