Naturally fluorescent proteins have revolutionized biology by enabling what was formerly
invisible to be seen clearly. These proteins have allowed us to visualize, in real time …

Fluorescence‐guided surgery can enhance the surgeon's ability to achieve a complete
oncologic resection. There are a number of tumor‐specific probes being developed with …

A patient with high grade undifferentiated pleomorphic soft-tissue sarcoma from a striated
muscle was grown orthotopically in the right biceps femoris muscle of mice to establish a …

Tumor-targeting Salmonella enterica serovar Typhimurium A1-R (Salmonella A1-R) had
strong efficacy on a melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse …

Ewing's sarcoma is a rare and aggressive malignancy. In the present study, tumor from a
patient with a Ewing's sarcoma with cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) …

Recombinant methioninase (rMETase) was previously administered as an injectable drug to
target methionine dependence of cancer. Recently, we observed that rMETase could be …

An excessive requirement for methionine termed methionine dependence, appears to be a
general metabolic defect in cancer. We have previously shown that cancer-cell growth can …

Melanoma is a recalcitrant disease in need of transformative therapuetics. The present study
used a patient-derived orthotopic xenograft (PDOX) nude-mouse model of melanoma with a …

In the present study, a patient-derived orthotopic xenograft (PDOX) model of recurrent
cisplatinum (CDDP)-resistant metastatic osteosarcoma was treated with Salmonella …

Melanoma is a recalcitrant disease. The present study used a patient-derived orthotopic
xenograft (PDOX) model of melanoma to test sensitivity to three molecularly-targeted drugs …