[HTML][HTML] Heterogeneity in malignant pleural mesothelioma

K Oehl, B Vrugt, I Opitz, M Meerang - International journal of molecular …, 2018 - mdpi.com
Despite advances in malignant pleural mesothelioma therapy, life expectancy of affected
patients remains short. The limited efficiency of treatment options is mainly caused by inter …

Malignant pleural mesothelioma: new hope in the horizon with novel therapeutic strategies

J Remon, N Reguart, J Corral, P Lianes - Cancer treatment reviews, 2015 - Elsevier
Malignant pleural mesothelioma (MPM) is a rare but aggressive malignancy of the pleura,
with a strong causal link to asbestos exposure. MPM incidence has been increasing in …

[HTML][HTML] Tumor suppressor microRNAs contribute to the regulation of PD-L1 expression in malignant pleural mesothelioma

SC Kao, YY Cheng, M Williams, MB Kirschner… - Journal of Thoracic …, 2017 - Elsevier
Introduction The upregulation of programmed death ligand 1 (PD-L1) is found in many
cancers and contributes to evasion of the host's immune defense. In malignant pleural …

[HTML][HTML] Anaplastic lymphoma kinase gene rearrangement in children and young adults with mesothelioma

I Mian, Z Abdullaev, B Morrow, RN Kaplan… - Journal of Thoracic …, 2020 - Elsevier
Introduction Children and young adults diagnosed with malignant mesothelioma may have
unique genetic characteristics. In this study, we evaluated for the presence of the anaplastic …

Acquired multiple mutations ALK I1171N, L1196M and G1202R mediate lorlatinib resistance in EML4-ALK-rearranged malignant pleural mesothelioma: a case report

J Hu, B Zhang, F Yao, Y Fu, D Chen… - Therapeutic …, 2020 - journals.sagepub.com
EML4-ALK rearranged malignant pleural mesothelioma (MPM) is rare and its responses to
anaplastic lymphoma kinase (ALK) inhibitors, including alectinib and lorlatinib, remain …

Anaplastic lymphoma kinase (ALK) translocation in paediatric malignant peritoneal mesothelioma: A case report of novel ALK‐related tumour spectrum

K Loharamtaweethong, N Puripat, N Aoonjai… - …, 2016 - Wiley Online Library
Aims To report a case of paediatric malignant peritoneal mesothelioma (MPM) with evidence
of anaplastic lymphoma kinase (ALK) translocation. Methods and results We describe a 10 …

[HTML][HTML] A subgroup of pleural mesothelioma expresses ALK protein and may be targetable by combined rapamycin and crizotinib therapy

D Mönch, S Bode-Erdmann, J Kalla, J Sträter… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Malignant pleural mesothelioma (MPM) is a neoplasm with inferior prognosis and notorious
chemotherapeutic resistance. Targeting aberrantly overexpressed kinases to cure MPM is a …

FISH analysis of crizotinib target genes ROS1/ALK/MET in malignant mesothelioma

S Salvi, S Varesano, S Boccardo, JL Ravetti… - Journal of Thoracic …, 2017 - jto.org
To the Editor: Malignant mesothelioma (MM) is a particularly aggressive tumor in which,
despite advances in chemotherapy, radiation therapy, and surgical management, the …

Association between lung cancer somatic mutations and occupational exposure in never-smokers

C Paris, P Do, B Mastroianni, A Dixmier… - European …, 2017 - Eur Respiratory Soc
Occupational exposure constitutes a common risk factor for lung cancer. We observed
molecular alterations in 73% of never-smokers, 35% of men and 8% of women were …

[HTML][HTML] Clinical Next Generation Sequencing Application in Mesothelioma: Finding a Golden Needle in the Haystack

L Cerbone, S Orecchia, P Bertino, S Delfanti… - Cancers, 2023 - mdpi.com
Simple Summary Mesothelioma is a rare cancer arising from the mesothelium, the epithelial
lining of the pleura, peritoneum, pericardium and tunica vaginalis testis. Mesothelioma is a …