Molecular physiology of membrane guanylyl cyclase receptors

M Kuhn - Physiological reviews, 2016 - journals.physiology.org
cGMP controls many cellular functions ranging from growth, viability, and differentiation to
contractility, secretion, and ion transport. The mammalian genome encodes seven …

Natriuretic peptides and cardiometabolic health

DK Gupta, TJ Wang - Circulation Journal, 2015 - jstage.jst.go.jp
Natriuretic peptides are cardiac-derived hormones with a range of protective functions,
including natriuresis, diuresis, vasodilation, lusitropy, lipolysis, weight loss, and improved …

Targeting luteinizing hormone-releasing hormone: a potential therapeutics to treat gynecological and other cancers

R Ghanghoria, P Kesharwani, RK Tekade… - Journal of Controlled …, 2018 - Elsevier
Cancer is a prime healthcare problem that is significantly responsible for universal mortality.
Despite distinguished advancements in medical field, chemotherapy is still the mainstay for …

[HTML][HTML] Modified natriuretic peptides and their potential roles in cancer treatment

M Xu, X Liu, P Li, Y Yang, W Zhang, S Zhao, Y Zeng… - biomedical …, 2022 - Elsevier
The natriuretic peptide family (NPs) is a group of natural endocrine hormones, containing a
17-amino acid ring structure connected by disulfide bonds of two cysteines. In this review …

[HTML][HTML] The Role of the Cardiac Biomarkers in the Renal Cell Carcinoma Multidisciplinary Management

A Drăgan, I Sinescu - Diagnostics, 2023 - mdpi.com
Renal cell carcinoma, an aggressive malignancy, is often incidentally diagnosed. The
patient remains asymptomatic to the late stage of the disease, when the local or distant …

CD73 on B16F10 melanoma cells in CD73-deficient mice promotes tumor growth, angiogenesis, neovascularization, macrophage infiltration and metastasis

P Koszałka, M Gołuńska, M Stanisławowski… - The international journal …, 2015 - Elsevier
Abstract Ecto-5′-nucleotidase (CD73), an enzyme providing interstitial adenosine,
mediates diverse physiological and pathological responses. In tumor progression, it has …

[HTML][HTML] Xanthatin inhibits corneal neovascularization by inhibiting the VEGFR2‑mediated STAT3/PI3K/Akt signaling pathway

M Shen, XZ Zhou, L Ye, Q Yuan… - International …, 2018 - spandidos-publications.com
Alkali burn is one of the main causes of corneal injury. The inflammation and
neovascularization caused by alkali burns aggravate corneal damage, resulting in loss of …

Natriuretic peptides: Another tool for the management of cancer?

J Balaguer, J García-Foncillas, J Tuñón - Critical Reviews in Oncology …, 2023 - Elsevier
The connection between heart failure (HF) and cancer through multiple pathways such as
inflammation, oxidative stress, and neurohormonal activation, among others, is well …

Biomimetic peptides for the treatment of cancer

Y Mine, H Munir, Y Nakanishi, D Sugiyama - Anticancer research, 2016 - ar.iiarjournals.org
Cancer remains one of the leading causes of death worldwide, indicating that current cancer
therapies are ineffective. Therefore, new treatments with high specificity and low toxicity are …

Apatinib inhibits angiogenesis in intrahepatic cholangiocarcinoma by regulating the vascular endothelial growth factor receptor-2/signal transducer and activator of …

MP Huang, SZ Gu, B Huang, GW Li, ZP Xiong, T Tang… - Pharmacology, 2021 - karger.com
Abstract Introduction: Intrahepatic cholangiocarcinoma (ICC), which is difficult to diagnose
and is usually fatal due to its late clinical presentation and a lack of effective treatment, has …