Cisplatin resistance and opportunities for precision medicine

L Amable - Pharmacological research, 2016 - Elsevier
Cisplatin is one of the most commonly used chemotherapy drugs, treating a wide range of
cancer types. Unfortunately, many cancers initially respond to platinum treatment but when …

[HTML][HTML] Nab-paclitaxel plus gemcitabine for metastatic pancreatic adenocarcinoma after Folfirinox failure: an AGEO prospective multicentre cohort

A Portal, S Pernot, D Tougeron, C Arbaud… - British journal of …, 2015 - nature.com
Background: There is currently no standard second-line treatment for metastatic pancreatic
adenocarcinoma (MPA), and progression-free survival is consistently< 4 months in this …

The complete structure of the human TFIIH core complex

BJ Greber, DB Toso, J Fang, E Nogales - Elife, 2019 - elifesciences.org
Transcription factor IIH (TFIIH) is a heterodecameric protein complex critical for transcription
initiation by RNA polymerase II and nucleotide excision DNA repair. The TFIIH core complex …

Five years update on relationships between malignant pleural mesothelioma and exposure to asbestos and other elongated mineral particles

P Andujar, A Lacourt, P Brochard… - Journal of Toxicology …, 2016 - Taylor & Francis
Despite the reduction of global asbestos consumption and production due to the ban or
restriction of asbestos uses in more than 50 countries since the 1970s, malignant …

Crocin synergistically enhances the antiproliferative activity of 5‐flurouracil through Wnt/PI3K pathway in a mouse model of colitis‐associated colorectal cancer

F Amerizadeh, N Rezaei, F Rahmani… - Journal of cellular …, 2018 - Wiley Online Library
Colorectal cancer (CRC) is the third most common cause of cancer‐related death, and
hence there is a need for the identification of novel‐agents to improve the efficacy of existing …

PNU‐74654 enhances the antiproliferative effects of 5‐FU in breast cancer and antagonizes thrombin‐induced cell growth via the Wnt pathway

F Rahmani, F Amerizadeh… - Journal of cellular …, 2019 - Wiley Online Library
The Wnt/β‐catenin pathway is one of the most common pathways dysregulated in breast
cancer, and may, therefore, be a potential‐therapeutic target. We have investigated the …

Are we still on the right path (way)?: the altered expression of the pentose phosphate pathway in solid tumors and the potential of its inhibition in combination therapy

CJW Meskers, M Franczak, RT Smolenski… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction The pentose phosphate pathway (PPP) branches from glycolysis and is crucial
for cell growth, since it provides necessary compounds for anabolic reactions, nucleotide …

Novel targeted strategies to overcome resistance in small-cell lung cancer: focus on PARP inhibitors and rovalpituzumab tesirine

R Van Den Borg, A Leonetti, M Tiseo… - Expert review of …, 2019 - Taylor & Francis
Introduction: Small-cell lung cancer (SCLC) is a highly aggressive neuroendocrine tumour,
and its outcome is strongly conditioned by the rapid onset of resistance to conventional …

[HTML][HTML] Predictive value of ERCC1, ERCC2, ERCC4, and glutathione S-Transferase Pi expression for the efficacy and safety of FOLFIRINOX in patients with …

S Tezuka, M Ueno, S Kobayashi… - American Journal of …, 2018 - ncbi.nlm.nih.gov
The platinum-based chemotherapy regimen FOLFIRINOX (leucovorin, fluorouracil,
irinotecan, and oxaliplatin) is currently used as a standard treatment for patients with …

Association of TNF‐308 G> A polymorphism located in tumor necrosis factor a with the risk of developing cervical cancer and results of pap smear

N Babapour, M Mehramiz… - Journal of cellular …, 2019 - Wiley Online Library
Tumor necrosis factor a (TNFa) is an inflammatory cytokine that plays a crucial role in the
immune response and the progression of cervical lesions. There is a growing body of data …