New carbocyclic N6-substituted adenine and pyrimidine nucleoside analogues with a bicyclo [2.2. 1] heptane fragment as sugar moiety; synthesis, antiviral, anticancer …

CI Tănase, C Drăghici, A Cojocaru… - Bioorganic & medicinal …, 2015 - Elsevier
New nucleoside analogues with an optically active bicyclo [2.2. 1] heptane skeleton as
sugar moiety and 6-substituted adenine were synthesized by alkylation of 6-chloropurine …

[HTML][HTML] 9-Norbornyl-6-chloropurine (NCP) induces cell death through GSH depletion-associated ER stress and mitochondrial dysfunction

P Plačková, M Šála, M Šmídková, M Dejmek… - Free Radical Biology …, 2016 - Elsevier
Norbornyl-6-chloropurine (NCP) is a representative of a series of antienteroviral bicycle
derivatives with selective cytotoxicity towards leukemia cell lines. In this work we explored …

New antitumor 6-chloropurine nucleosides inducing apoptosis and G2/M cell cycle arrest

S Schwarz, B Siewert, R Csuk, AP Rauter - European Journal of Medicinal …, 2015 - Elsevier
Treating cancer has been challenging for decades, following countless approaches and
attempts. Nucleosides, alone or as part of nucleotides, are vital elements of living systems …

Synthesis of Novel Purine‐Based Coxsackievirus Inhibitors Bearing Polycylic Substituents at the N‐9 Position

M Dejmek, M Šála, P Plačková… - Archiv der …, 2014 - Wiley Online Library
The synthesis of a novel library of purine derivatives bearing various bicyclic and polycylic
substituents at the N‐9 position is described. The series includes norbornanes, bicyclo [2.2 …

[PDF][PDF] New constrained Amines in a Bicyclo [2.2. 1] heptane Skeleton

CI Tanase, C Draghici, C Negut, L Pintilie - REVISTA DE CHIMIE, 2018 - researchgate.net
In this paper we present an efficient procedure for obtaining ether-protected bicyclo [2.2. 1]
heptane amines in six steps, from an optically active keto-alcohol norbornane compound, for …

Transport mechanisms of a novel antileukemic and antiviral compound 9-norbornyl-6-chloropurine

P Plačková, H Hřebabecký, M Šála… - Journal of Enzyme …, 2015 - Taylor & Francis
Chloropurines substituted at the position 9 with variously modified bicyclic skeletons
represent promising antiviral and anticancer agents. This work aimed to investigate the …

Nízkomolekulární inhibitory replikace enterovirů

R Nencka, H Hřebabecký, M Šála… - Chemické listy, 2014 - ww-w.chemicke-listy.cz
Enteroviruses rank among the most common human pathogens; millions of people suffer
from diseases caused by them every year. However, no specific treatment of infections …

[CITATION][C] TUE-155

D Kosek