Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy

E Pérez-Herrero, A Fernández-Medarde - European journal of …, 2015 - Elsevier
Cancer is the second worldwide cause of death, exceeded only by cardiovascular diseases.
It is characterized by uncontrolled cell proliferation and an absence of cell death that, except …

Hyperthermia can alter tumor physiology and improve chemo-and radio-therapy efficacy

M Dunne, M Regenold, C Allen - Advanced Drug Delivery Reviews, 2020 - Elsevier
Hyperthermia has demonstrated clinical success in improving the efficacy of both chemo-
and radio-therapy in solid tumors. Pre-clinical and clinical research studies have …

[HTML][HTML] Low-energy electron damage to condensed-phase DNA and its constituents

Y Gao, Y Zheng, L Sanche - International Journal of Molecular Sciences, 2021 - mdpi.com
The complex physical and chemical reactions between the large number of low-energy (0–
30 eV) electrons (LEEs) released by high energy radiation interacting with genetic material …

Dual-drug delivery of curcumin and platinum drugs in polymeric micelles enhances the synergistic effects: a double act for the treatment of multidrug-resistant cancer

W Scarano, P De Souza, MH Stenzel - Biomaterials science, 2015 - pubs.rsc.org
Combinational chemotherapy is often used to prevent drug induced resistance in cancer.
The aim of this work is to test whether the co-delivery of drugs within one nanoparticle can …

The Physico‐Chemical Basis of DNA Radiosensitization: Implications for Cancer Radiation Therapy

R Schürmann, S Vogel, K Ebel… - Chemistry–A European …, 2018 - Wiley Online Library
High‐energy radiation is used in combination with radiosensitizing therapeutics to treat
cancer. The most common radiosensitizers are halogenated nucleosides and cisplatin …

[HTML][HTML] Convection-enhanced delivery in malignant gliomas: a review of toxicity and efficacy

M Shi, L Sanche - Journal of oncology, 2019 - hindawi.com
Malignant gliomas are undifferentiated or anaplastic gliomas. They remain incurable with a
multitude of modalities, including surgery, radiation, chemotherapy, and alternating electric …

Clustered DNA damage induced by 2–20 eV electrons and transient anions: general mechanism and correlation to cell death

Y Dong, Y Gao, W Liu, T Gao, Y Zheng… - The Journal of …, 2019 - ACS Publications
The mechanisms of action of low-energy electrons (LEEs) generated in large quantities by
ionizing radiation constitute an essential element of our understanding of early events in …

High cytotoxic effect by combining copper-64 with a nota–terpyridine platinum conjugate

M Khosravifarsani, S Ait-Mohand… - Journal of Medicinal …, 2021 - ACS Publications
Terpyridine platinum (TP)-based chemotherapeutic agents target three-dimensional
structures on DNA known as G-quadruplexes. We report the rational design and synthesis of …

Pre-clinical research in small animals using radiotherapy technology–a bidirectional translational approach

F Tillner, P Thute, R Buetof, M Krause… - Zeitschrift für Medizinische …, 2014 - Elsevier
For translational cancer research, pre-clinical in-vivo studies using small animals have
become indispensable in bridging the gap between in-vitro cell experiments and clinical …

The exploitation of low-energy electrons in cancer treatment

M Rezaee, RP Hill, DA Jaffray - Radiation research, 2017 - meridian.allenpress.com
Given the distinct characteristics of low-energy electrons (LEEs), particularly at energies less
than 30 eV, they can be applied to a wide range of therapeutic modalities to improve cancer …