Cisplatin, oxaliplatin, paclitaxel, vincristine and bortezomib are some of the most effective
drugs successfully employed (alone or in combinations) as first-line treatment for common …

Peripheral neuropathies are characterized by nerves damage and axonal loss, and they
could be classified in hereditary or acquired forms. Acquired peripheral neuropathies are …

Chemotherapy-induced peripheral neuropathy is a common side effect of selected
chemotherapeutic agents. Previous work has suggested that patients often under report the …

Proteasome inhibitors (PIs), especially bortezomib (BTZ), have come to the forefront over the
last years because of their unprecedented efficacy mainly against multiple myeloma (MM) …

Cancer and its treatment exert a heavy psychological and physical toll. Of the myriad
symptoms which result, pain is common, encountered in between 30% and 60% of cancer …

Simple Summary Multiple myeloma (MM) is a still uncurable tumor of mainly elderly patients
originating from the terminally differentiated B cells. Introduction to the treatment of MM …

Background Chemotherapy-induced peripheral neurotoxicity (CIPN) is a severe adverse
effect in patients receiving antitumor agents, and no effective treatment is available …

This review paper provides a critical exploration of updates concerning the spectrum of
characteristics and treatment options of bortezomib-induced peripheral neuropathy (BIPN) …

Vincristine and bortezomib are effective chemotherapeutics widely used to treat
hematological cancers. Vincristine blocks tubulin polymerization, whereas bortezomib is a …

Bortezomib (BTZ) is used as a chemotherapeutic agent for the treatment of multiple
myeloma. Nevertheless, one of the significant limiting complications of BTZ is painful …