TOR (target of rapamycin) and its mammalian ortholog mTOR have been discovered in an
effort to understand the mechanisms of action of the immunosuppressant drug rapamycin …

Medulloblastoma (MB) is the most common malignant pediatric posterior fossa tumor.
Recent genetic, epigenetic, and transcriptomic analyses have classified MB into three …

Opinion statement Medulloblastoma (MB) is the most common pediatric brain malignancy,
with a 5-year overall survival (OS) rate of around 65%. The conventional MB treatment …

Medulloblastoma (MB) is the most frequent malignant brain tumor in children. Patients with
MB who are classified as having high-risk disease or those with recurrent disease respond …

Medulloblastoma, a common malignant brain tumor in children, consists of four molecular
subgroups WNT, SHH, Group 3 and Group 4. Group 3, Group 4 tumors have an overlap in …

The hedgehog (Hh) pathway is highly conserved and required for embryonic patterning and
determination. Mutations in the Hh pathway are observed in sporadic tumors as well as …

The mTOR pathway controls mRNA translation of mitogenic proteins and is a central
regulator of metabolism in malignant cells. Development of malignant cell resistance is a …

Opinion statement Medulloblastoma is the most frequently diagnosed primary malignant
brain tumor among children. Currently available therapeutic strategies are based on surgical …

The hedgehog (Hh) signaling pathway is an important therapeutic target in cancer;
involvement of the Hh pathway has been shown in a variety of cancers including basal cell …

Background/Aims: Ligustrazine (LSZ) has been identified as an antitumor agent against
some types of cancers. Nevertheless, its ability to inhibit growth, migration and invasion of …