The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer
This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …
level. First, the interactions between curcumin and its molecular targets are addressed on …
[HTML][HTML] Antimetastatic effects of curcumin in oral and gastrointestinal cancers
Gastrointestinal (GI) cancers are known as frequently occurred solid malignant tumors that
can cause the high rate mortality in the world. Metastasis is a significant destructive feature …
can cause the high rate mortality in the world. Metastasis is a significant destructive feature …
[HTML][HTML] A phase 1 dose-escalation study on the safety, tolerability and activity of liposomal curcumin (Lipocurc™) in patients with locally advanced or metastatic …
Purpose This study was conducted to investigate the safety and tolerability of increasing
doses of liposomal curcumin in patients with metastatic cancer. Investigations of anti-tumor …
doses of liposomal curcumin in patients with metastatic cancer. Investigations of anti-tumor …
[PDF][PDF] Safety, tolerability and pharmacokinetics of liposomal curcumin (Lipocurc™) in healthy humans
A Storka, B Vcelar, U Klickovic, G Gouya… - Int. J. Clin. Pharmacol …, 2015 - academia.edu
Introduction: Experimental studies have shown that liposomal curcumin can exert a
reduction in tumor growth in pancreatic and colorectal cancer. In this phase I clinical trial we …
reduction in tumor growth in pancreatic and colorectal cancer. In this phase I clinical trial we …
Curcumin promotes autophagic survival of a subset of colon cancer stem cells, which are ablated by DCLK1-siRNA
C Kantara, M O'Connell, S Sarkar, S Moya, R Ullrich… - Cancer research, 2014 - AACR
Curcumin is known to induce apoptosis of cancer cells by different mechanisms, but its
effects on cancer stem cells (CSC) have been less investigated. Here, we report that …
effects on cancer stem cells (CSC) have been less investigated. Here, we report that …
Review of dietary supplements for the management of osteoarthritis in dogs in studies from 2004 to 2014
F Comblain, S Serisier, N Barthelemy… - Journal of veterinary …, 2016 - Wiley Online Library
Osteoarthritis (OA) is a chronic, painful, degenerative and inflammatory disease that affects
the synovial joints and leads finally to the loss of mobility. It is highly prevalent in dogs …
the synovial joints and leads finally to the loss of mobility. It is highly prevalent in dogs …
Bringing curcumin to the clinic in cancer prevention: a review of strategies to enhance bioavailability and efficacy
Curcumin is widely available, inexpensive spice that has been used in ancient folk medicine
for millennia, especially in India. Curcumin has the pharmacological properties that slow or …
for millennia, especially in India. Curcumin has the pharmacological properties that slow or …
Novel curcumin oral delivery systems
T Kurita, Y Makino - Anticancer research, 2013 - ar.iiarjournals.org
Curcumin, a natural polyphenolic compound derived from turmeric (Curcuma longa L), has
proven to be a modulator of multiple intercellular signalling pathways linked to inflammation …
proven to be a modulator of multiple intercellular signalling pathways linked to inflammation …
Catanionic lipid nanosystems improve pharmacokinetics and anti-lung cancer activity of curcumin
S Li, C Fang, J Zhang, B Liu, Z Wei, X Fan, Z Sui… - … , Biology and Medicine, 2016 - Elsevier
Novel catanionic lipid nanosystems (CLNs) incorporating curcumin (CCM) were developed,
and improvements in pharmacokinetics and enhanced anti-lung cancer activity were …
and improvements in pharmacokinetics and enhanced anti-lung cancer activity were …
[HTML][HTML] Application of biocompatible drug delivery nanosystems for the treatment of naturally occurring cancer in dogs
Background: Cancer is a common disease in dogs, with a growing incidence related to the
age of the animal. Nanotechnology is being employed in the veterinary field in the same …
age of the animal. Nanotechnology is being employed in the veterinary field in the same …