The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer

M Heger, RF van Golen, M Broekgaarden… - Pharmacological …, 2014 - ASPET
This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …

[HTML][HTML] Antimetastatic effects of curcumin in oral and gastrointestinal cancers

A Davoodvandi, H Khan, M Aschner… - Frontiers in …, 2021 - frontiersin.org
Gastrointestinal (GI) cancers are known as frequently occurred solid malignant tumors that
can cause the high rate mortality in the world. Metastasis is a significant destructive feature …

[HTML][HTML] A phase 1 dose-escalation study on the safety, tolerability and activity of liposomal curcumin (Lipocurc) in patients with locally advanced or metastatic …

R Greil, S Greil-Ressler, L Weiss, C Schönlieb… - Cancer chemotherapy …, 2018 - Springer
Purpose This study was conducted to investigate the safety and tolerability of increasing
doses of liposomal curcumin in patients with metastatic cancer. Investigations of anti-tumor …

[PDF][PDF] Safety, tolerability and pharmacokinetics of liposomal curcumin (Lipocurc™) in healthy humans

A Storka, B Vcelar, U Klickovic, G Gouya… - Int. J. Clin. Pharmacol …, 2015 - academia.edu
Introduction: Experimental studies have shown that liposomal curcumin can exert a
reduction in tumor growth in pancreatic and colorectal cancer. In this phase I clinical trial we …

Curcumin promotes autophagic survival of a subset of colon cancer stem cells, which are ablated by DCLK1-siRNA

C Kantara, M O'Connell, S Sarkar, S Moya, R Ullrich… - Cancer research, 2014 - AACR
Curcumin is known to induce apoptosis of cancer cells by different mechanisms, but its
effects on cancer stem cells (CSC) have been less investigated. Here, we report that …

Review of dietary supplements for the management of osteoarthritis in dogs in studies from 2004 to 2014

F Comblain, S Serisier, N Barthelemy… - Journal of veterinary …, 2016 - Wiley Online Library
Osteoarthritis (OA) is a chronic, painful, degenerative and inflammatory disease that affects
the synovial joints and leads finally to the loss of mobility. It is highly prevalent in dogs …

Bringing curcumin to the clinic in cancer prevention: a review of strategies to enhance bioavailability and efficacy

RI Mahran, MM Hagras, D Sun, DE Brenner - The AAPS journal, 2017 - Springer
Curcumin is widely available, inexpensive spice that has been used in ancient folk medicine
for millennia, especially in India. Curcumin has the pharmacological properties that slow or …

Novel curcumin oral delivery systems

T Kurita, Y Makino - Anticancer research, 2013 - ar.iiarjournals.org
Curcumin, a natural polyphenolic compound derived from turmeric (Curcuma longa L), has
proven to be a modulator of multiple intercellular signalling pathways linked to inflammation …

Catanionic lipid nanosystems improve pharmacokinetics and anti-lung cancer activity of curcumin

S Li, C Fang, J Zhang, B Liu, Z Wei, X Fan, Z Sui… - … , Biology and Medicine, 2016 - Elsevier
Novel catanionic lipid nanosystems (CLNs) incorporating curcumin (CCM) were developed,
and improvements in pharmacokinetics and enhanced anti-lung cancer activity were …

[HTML][HTML] Application of biocompatible drug delivery nanosystems for the treatment of naturally occurring cancer in dogs

N Ambrosio, S Voci, A Gagliardi, E Palma… - Journal of Functional …, 2022 - mdpi.com
Background: Cancer is a common disease in dogs, with a growing incidence related to the
age of the animal. Nanotechnology is being employed in the veterinary field in the same …