Macrophages in the microenvironment of head and neck cancer: potential targets for cancer therapy

D Evrard, P Szturz, A Tijeras-Raballand… - Oral oncology, 2019 - Elsevier
The microenvironment of solid tumors has become a promising target for future therapies
modulating immune cells. Patients with advanced head and neck cancer, which still …

Preclinical intravital microscopy of the tumour-stroma interface: invasion, metastasis, and therapy response

S Alexander, B Weigelin, F Winkler, P Friedl - Current opinion in cell …, 2013 - Elsevier
Key steps of cancer progression and therapy response depend upon interactions between
cancer cells with the reactive tumour microenvironment. Intravital microscopy enables multi …

[HTML][HTML] Crosstalk between colon cancer cells and macrophages via inflammatory mediators and CD47 promotes tumour cell migration

Y Zhang, W Sime, M Juhas, A Sjölander - European journal of cancer, 2013 - Elsevier
Tumour-associated macrophages (TAMs) of the M2 phenotype are present in the stroma of
many tumours and are frequently associated with the progression of several types of cancer …

[HTML][HTML] Application of GFP imaging in cancer

RM Hoffman - Laboratory investigation, 2015 - Elsevier
Multicolored proteins have allowed the color-coding of cancer cells growing in vivo and
enabled the distinction of host from tumor with single-cell resolution. Non-invasive imaging …

The importance of the tumor microenvironment in the therapeutic management of cancer

C Pottier, A Wheatherspoon, P Roncarati… - Expert review of …, 2015 - Taylor & Francis
Tumor prognosis is generally defined by various tumor parameters. However, it is well
known that paracrine, endocrine and cell–cell interactions between the tumor and its …

Cancer stem cells, cancer-initiating cells and methods for their detection

S Akbari-Birgani, T Paranjothy, A Zuse, T Janikowski… - Drug discovery today, 2016 - Elsevier
Highlights•Improved early cancer detection, combined with better therapeutic monitoring
procedures and dynamic treatment options, is needed to combat tumor persistence …

Conditioning solid tumor microenvironment through inflammatory chemokines and S100 family proteins

MW Nasser, M Elbaz, DK Ahirwar, RK Ganju - Cancer letters, 2015 - Elsevier
Recently, there has been growing attention to the role of the tumor microenvironment (TME)
in cancer growth, metastasis and emergence of chemotherapy resistance. Stromal and …

[HTML][HTML] MUC1 selectively targets human pancreatic cancer in orthotopic nude mouse models

JY Park, Y Hiroshima, JY Lee, AA Maawy, RM Hoffman… - PloS one, 2015 - journals.plos.org
The goal of this study was to determine whether MUC1 antibody conjugated with a
fluorophore could be used to visualize pancreatic cancer. Anti-MUC1 (CT2) antibody was …

Imaging UVC‐induced DNA damage response in models of minimal cancer

S Miwa, S Yano, Y Hiroshima, Y Tome… - Journal of cellular …, 2013 - Wiley Online Library
We have previously demonstrated that the ultraviolet (UV) light is effective against a variety
of cancer cells in vivo as well as in vitro. In the present report, we imaged the DNA damage …

Comparison of UVB and UVC effects on the DNA damage‐response protein 53BP1 in human pancreatic cancer

F Uehara, S Miwa, Y Tome, Y Hiroshima… - Journal of cellular …, 2014 - Wiley Online Library
We have previously demonstrated that ultraviolet (UV) light is effective against a variety of
cancer cells expressing fluorescent proteins in vivo as well as in vitro. In the present report …