Vitamin D and its synthetic analogs

MA Maestro, F Molnar, C Carlberg - Journal of Medicinal …, 2019 - ACS Publications
For many individuals, in particular during winter, supplementation with the secosteroid
vitamin D3 is essential for the prevention of bone disorders, muscle weakness, autoimmune …

A survey of the role of noncovalent sulfur interactions in drug design

BR Beno, KS Yeung, MD Bartberger… - Journal of medicinal …, 2015 - ACS Publications
Electron deficient, bivalent sulfur atoms have two areas of positive electrostatic potential, a
consequence of the low-lying σ* orbitals of the C–S bond that are available for interaction …

[HTML][HTML] Structural considerations of vitamin D signaling

F Molnár - Frontiers in physiology, 2014 - frontiersin.org
Crystal structures represent the static picture in the life of a molecule giving a sneak preview
what it might be in reality. Hence, it is very hard to extrapolate from these photos toward …

[HTML][HTML] IKZF1 genetic variants rs4132601 and rs11978267 and acute lymphoblastic leukemia risk in Tunisian children: a case-control study

S Mahjoub, V Chayeb, H Zitouni, RM Ghali… - BMC Medical …, 2019 - Springer
Background Associations between IKZF1 gene variants and Acute Lymphoblastic Leukemia
(ALL) was recently reported. We examined whether the common IKZF1 polymorphisms …

[HTML][HTML] Relationship between structure and conformational change of the vitamin D receptor ligand binding domain in 1α, 25-dihydroxyvitamin D3 signaling

LY Wan, YQ Zhang, MD Chen, YQ Du, CB Liu, JF Wu - Molecules, 2015 - mdpi.com
Vitamin D Receptor (VDR) belongs to the nuclear receptor (NR) superfamily. Whereas the
structure of the ligand binding domain (LBD) of VDR has been determined in great detail …

TEI-A00114: a new vitamin D3 analogue that inhibits neutrophil recruitment in an acute lung injury hamster model while showing reduced hypercalcemic activity

Y Takano, H Mitsuhashi, S Ishizuka, K Takahashi… - Steroids, 2012 - Elsevier
While searching for vitamin D 3 analogues which inhibit neutrophil recruitment in the lung
without elevating plasma calcium level, we found that (5Z, 7E)-(1S, 3R)-20 (R)-[(5E)-(2S)-2 …

Vitamin D and Its Synthetic Analogs

M Miguel A, M Ferdinand, C Carsten - 2019 - nur.nu.edu.kz
For many individuals, in particular during winter, supplementation with the secosteroid
vitamin D3 is essential for the prevention of bone disorders, muscle weakness, autoimmune …

[PDF][PDF] 炎症性肺疾患における好中球浸潤抑制作用を有する新規ビタミン D3 誘導体の創薬研究

高野泰宏 - 2013 - opac.ll.chiba-u.jp
ALI: acute lung injury ARDS: acute respiratory distress syndrome BAL: bronchoalveolar
lavage BALF: bronchoalveolar lavage fluid CF: cystic fibrosis CINC: cytokine-induced …