[HTML][HTML] PTEN inhibition in human disease therapy

R Pulido - Molecules, 2018 - mdpi.com
The tumor suppressor PTEN is a major homeostatic regulator, by virtue of its lipid
phosphatase activity against phosphatidylinositol 3, 4, 5-trisphosphate [PI (3, 4, 5) P3], which …

[HTML][HTML] Role of PTEN-less in cardiac injury, hypertrophy and regeneration

T Liang, F Gao, J Chen - Cell Regeneration, 2021 - Springer
Cardiovascular diseases are the leading cause of death worldwide. Cardiomyocytes are
capable of coordinated contractions, which are mainly responsible for pumping blood. When …

PTEN inhibitors: an evaluation of current compounds

L Spinelli, YE Lindsay, NR Leslie - Advances in biological regulation, 2015 - Elsevier
Small molecule inhibitors of many classes of enzymes, including phosphatases, have
widespread use as experimental tools and as therapeutics. Efforts to develop inhibitors …

[PDF][PDF] 5‐Hydroxytryptamine receptor 1D aggravates hepatocellular carcinoma progression through FoxO6 in AKT‐dependent and independent manners

X Zuo, Z Chen, J Cai, W Gao, Y Zhang, G Han… - …, 2019 - Wiley Online Library
Serotonin and its receptors have been shown to play critical regulatory roles in cancer
biology. Nevertheless, the contributions of 5‐hydroxytryptamine 1D (5‐HT1D), an …

IDO1 Is a Therapeutic Target for Pancreatic Cancer–Associated Depression

JJ Hue, HJ Graor, M Zarei, ES Katayama, K Ji… - Molecular Cancer …, 2022 - AACR
Metabolites of tryptophan degradation are known to alter mood. Their effects have only been
superficially examined in the context of pancreatic cancer. Herein, we study the role of …

Cotargeting the PI3K and RAS pathways for the treatment of neuroendocrine tumors

JD Valentino, J Li, YY Zaytseva, WC Mustain… - Clinical Cancer …, 2014 - AACR
Background: The precise involvement of the PI3K/mTOR and RAS/MEK pathways in
carcinoid tumors is not well defined. Therefore, the purpose of our study was to evaluate the …

[HTML][HTML] Carcinoid syndrome: preclinical models and future therapeutic strategies

G Vitale, S Carra, Y Alessi, F Campolo… - International Journal of …, 2023 - mdpi.com
Carcinoid syndrome represents a debilitating paraneoplastic disease, caused by the
secretion of several substances, occurring in about 10–40% of patients with well …

[HTML][HTML] Neuron membrane trafficking and protein kinases involved in autism and ADHD

Y Kitagishi, A Minami, A Nakanishi, Y Ogura… - International Journal of …, 2015 - mdpi.com
A brain-enriched multi-domain scaffolding protein, neurobeachin has been identified as a
candidate gene for autism patients. Mutations in the synaptic adhesion protein cell adhesion …

A PTEN inhibitor displays preclinical activity against hepatocarcinoma cells

G Augello, R Puleio, MR Emma, A Cusimano… - Cell Cycle, 2016 - Taylor & Francis
Phosphatase and tensin homolog (P TEN) gene is considered a tumor suppressor gene.
However, PTEN mutations rarely occur in hepatocellular carcinoma (HCC), whereas …

[HTML][HTML] IL-13-mediated immunological control of enterochromaffin cell hyperplasia and serotonin production in the gut

M Manocha, MS Shajib, MM Rahman, H Wang… - Mucosal …, 2013 - nature.com
Enterochromaffin (EC) cells in the gastrointestinal (GI) mucosa are the main source of
serotonin (5-hydroxytryptamine (5-HT)) in the body. 5-HT is implicated in the …