[HTML][HTML] Quantitative proteomics of the cancer cell line encyclopedia

DP Nusinow, J Szpyt, M Ghandi, CM Rose… - Cell, 2020 - Elsevier
Proteins are essential agents of biological processes. To date, large-scale profiling of cell
line collections including the Cancer Cell Line Encyclopedia (CCLE) has focused primarily …

Exosomal proteins as potential diagnostic markers in advanced non-small cell lung carcinoma

KR Jakobsen, BS Paulsen, R Bæk… - Journal of …, 2015 - Taylor & Francis
Background Lung cancer is one of the leading causes of cancer-related death. At the time of
diagnosis, more than half of the patients will have disseminated disease and, yet …

[HTML][HTML] NSCLC and HER2: between lights and shadows

GRR Ricciardi, A Russo, T Franchina, G Ferraro… - Journal of Thoracic …, 2014 - Elsevier
The therapeutic landscape of non–small-cell lung cancer (NSCLC) has dramatically
changed in the last few years with the introduction of molecularly targeted agents, leading to …

Tarloxotinib is a hypoxia-activated pan-HER kinase inhibitor active against a broad range of HER-family oncogenes

A Estrada-Bernal, AT Le, AE Doak, VG Tirunagaru… - Clinical Cancer …, 2021 - AACR
Purpose: Approved therapies for EGFR exon 20, ERBB2 mutations, and NRG1 fusions are
currently lacking for non–small cell lung cancer and other cancers. Tarloxotinib is a prodrug …

Current drugs and drug targets in non-small cell lung cancer: limitations and opportunities

A Daga, A Ansari, S Patel, S Mirza… - Asian Pacific Journal …, 2015 - koreascience.kr
Lung cancer is a serious health problem and leading cause of death worldwide due to its
high incidence and mortality. More than 80% of lung cancers feature a non-small cell …

Nanoscale mapping of EGFR and c-MET protein environments on lung cancer cell surfaces via therapeutic antibody photocatalyst conjugates

T Reyes-Robles, AK Olow, TJ Bechtel… - ACS Chemical …, 2022 - ACS Publications
Receptor tyrosine kinases are involved in essential signaling roles that impact cell growth,
differentiation, and proliferation. The overexpression or mutation of these proteins can lead …

[HTML][HTML] Vestigial-like 1 is a shared targetable cancer-placenta antigen expressed by pancreatic and basal-like breast cancers

SD Bradley, AH Talukder, I Lai, R Davis… - Nature …, 2020 - nature.com
Cytotoxic T lymphocyte (CTL)-based cancer immunotherapies have shown great promise for
inducing clinical regressions by targeting tumor-associated antigens (TAA). To expand the …

Cisplatin influences acquisition of resistance to molecular‐targeted agents through epithelial–mesenchymal transition‐like changes

M Kurokawa, N Ise, K Omi, K Goishi… - Cancer …, 2013 - Wiley Online Library
Chemotherapy with platinum agents is the standard of care for non‐small‐cell lung cancer
(NSCLC); however, novel molecular‐targeted agents like gefitinib have been approved for …

[HTML][HTML] MiRNA-125a-5p: a regulator and predictor of gefitinib's effect on nasopharyngeal carcinoma

Y Liu, Z Li, L Wu, Z Wang, X Wang, Y Yu, Q Zhao… - Cancer Cell …, 2014 - Springer
Background Nasopharyngeal carcinoma (NPC) is a common malignancy in China and
Southeast Asia. Radiotherapy is the major treatment modality for patients with NPC, but …

89Zr-chloride can be used for immuno-PET radiochemistry without loss of antigen reactivity in vivo

DN Pandya, NB Bhatt, F Almaguel… - Journal of Nuclear …, 2019 - Soc Nuclear Med
89Zr immuno-PET continues to be assessed in numerous clinical trials. This report
evaluates the use of 89Zr-chloride in the radiolabeling of monoclonal antibodies conjugated …