Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update

N Takebe, L Miele, PJ Harris, W Jeong… - Nature reviews Clinical …, 2015 - nature.com
During the past decade, cancer stem cells (CSCs) have been increasingly identified in many
malignancies. Although the origin and plasticity of these cells remain controversial, tumour …

[HTML][HTML] Notch signaling in vascular endothelial cells, angiogenesis, and tumor progression: an update and prospective

A Akil, AK Gutiérrez-García, R Guenter… - Frontiers in cell and …, 2021 - frontiersin.org
The Notch signaling pathway plays an essential role in a wide variety of biological
processes including cell fate determination of vascular endothelial cells and the regulation …

Targeting notch signaling pathway in cancer: clinical development advances and challenges

N Takebe, D Nguyen, SX Yang - Pharmacology & therapeutics, 2014 - Elsevier
Notch signaling plays an important role in development and cell fate determination, and it is
deregulated in human hematologic malignancies and solid tumors. This review includes a …

[HTML][HTML] Resistance to trastuzumab

S Vivekanandhan, KL Knutson - Cancers, 2022 - mdpi.com
Simple Summary Trastuzumab is a humanized antibody that has significantly improved the
management and treatment outcomes of patients with cancers that overexpress HER2 …

[PDF][PDF] Increased cholesterol biosynthesis is a key characteristic of breast cancer stem cells influencing patient outcome

S Ehmsen, MH Pedersen, G Wang, MG Terp… - Cell reports, 2019 - cell.com
Tumor eradication may be greatly improved by targeting cancer stem cells (CSCs), as they
exhibit resistance to conventional therapy. To gain insight into the unique biology of CSCs …

Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy

SM McAuliffe, SL Morgan, GA Wyant… - Proceedings of the …, 2012 - National Acad Sciences
Chemoresistance to platinum therapy is a major obstacle that needs to be overcome in the
treatment of ovarian cancer patients. The high rates and patterns of therapeutic failure seen …

Notch inhibitors for cancer treatment

I Espinoza, L Miele - Pharmacology & therapeutics, 2013 - Elsevier
Notch signaling is an evolutionarily conserved cell signaling pathway involved in cell fate
during development, stem cell renewal and differentiation in postnatal tissues. Roles for …

[HTML][HTML] Breast cancer: molecular mechanisms of underlying resistance and therapeutic approaches

M Tufail, J Cui, C Wu - American journal of cancer research, 2022 - ncbi.nlm.nih.gov
Breast cancer (BC) affects over 250,000 women in the US each year. Drug-resistant cancer
cells are responsible for most breast cancer fatalities. Scientists are developing novel …

[HTML][HTML] Notch signaling in breast cancer: a role in drug resistance

MK BeLow, C Osipo - Cells, 2020 - mdpi.com
Breast cancer is a heterogeneous disease that can be subdivided into unique molecular
subtypes based on protein expression of the Estrogen Receptor, Progesterone Receptor …

RETRACTED: Notch-1 induces epithelial–mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells

B Bao, Z Wang, S Ali, D Kong, Y Li, A Ahmad… - 2011 - Elsevier
Activation of Notch-1 is known to be associated with the development and progression of
human malignancies including pancreatic cancer. Emerging evidence suggest that the …