Molecular biology of lung cancer: clinical implications

JE Larsen, JD Minna - Clinics in chest medicine, 2011 - chestmed.theclinics.com
Lung cancer is the leading cause of cancer-related death in men and women in the United
States, accounting for approximately 28% of total cancer deaths in 2010 despite comprising …

ZEB1-responsive genes in non-small cell lung cancer

RM Gemmill, J Roche, VA Potiron, P Nasarre, M Mitas… - Cancer letters, 2011 - Elsevier
The epithelial to mesenchymal transition (EMT) is a developmental process enabling
epithelial cells to gain a migratory mesenchymal phenotype. In cancer, this process …

EMT promoting transcription factors as prognostic markers in human breast cancer

M Matysiak, L Kapka-Skrzypczak… - Archives of gynecology …, 2017 - Springer
Purpose Breast cancer is one of the most common female cancers. Moreover, despite the
progress in medicine, its mortality rate is still very high. Therefore, researchers are constantly …

Overexpression of ZEB2 at the Invasion Front of Colorectal Cancer Is an Independent Prognostic Marker and Regulates Tumor Invasion In Vitro

C Kahlert, S Lahes, P Radhakrishnan, S Dutta… - Clinical cancer …, 2011 - AACR
Purpose: Epithelial-to-mesenchymal transition (EMT) plays a pivotal role in tumor invasion
and dissemination. EMT occurs predominantly at the tumor edge where it is induced by …

Vimentin, zeb1 and Sip1 are up-regulated in triple-negative and basal-like breast cancers: association with an aggressive tumour phenotype

P Karihtala, P Auvinen, S Kauppila… - Breast cancer research …, 2013 - Springer
In epithelial-to-mesenchymal transition (EMT) epithelial cancer cells achieve mesenchymal
features, essentially helping them to metastasize. There is some evidence that EMT could be …

β-Arrestin-1 mediates nicotine-induced metastasis through E2F1 target genes that modulate epithelial–mesenchymal transition

S Pillai, J Trevino, B Rawal, S Singh, M Kovacs, X Li… - Cancer research, 2015 - AACR
Cigarette smoking is a major risk factor in the development of non–small cell lung cancer
(NSCLC), which accounts for 80% of all lung cancers. Nicotine, the major addictive …

[HTML][HTML] Pellino-1 promotes lung carcinogenesis via the stabilization of Slug and Snail through K63-mediated polyubiquitination

YK Jeon, CK Kim, KR Hwang, HY Park, J Koh… - Cell Death & …, 2017 - nature.com
Pellino-1 is an E3 ubiquitin ligase acting as a critical mediator for a variety of immune
receptor signaling pathways, including Toll-like receptors, interleukin-1 receptor and T-cell …

[HTML][HTML] Down-regulation of microRNA-144 in air pollution-related lung cancer

HL Pan, ZS Wen, YC Huang, X Cheng, GZ Wang… - Scientific reports, 2015 - nature.com
Air pollution has been classified as a group 1 carcinogen in humans, but the underlying
tumourigenic mechanisms remain unclear. In Xuanwei city of Yunnan Province, the lung …

ZEB2 zinc-finger missense mutations lead to hypomorphic alleles and a mild Mowat–Wilson syndrome

J Ghoumid, L Drevillon, SM Alavi-Naini… - Human molecular …, 2013 - academic.oup.com
Mowat–Wilson syndrome (MWS) is a severe intellectual disability (ID)-distinctive facial
gestalt-multiple congenital anomaly syndrome, commonly associating microcephaly …

Smad4 and epithelial–mesenchymal transition proteins in colorectal carcinoma: an immunohistochemical study

M Ioannou, E Kouvaras, R Papamichali… - Journal of molecular …, 2018 - Springer
Epithelial–mesenchymal transition (EMT) plays an important role in cancer metastasis.
During EMT, tumor cells acquire the capacity to migrate and invade the stroma. Activation of …