The standard of care (SOC) for high-grade gliomas (HGG) is maximally safe surgical
resection, followed by concurrent radiation therapy (RT) and temozolomide (TMZ) for 6 …

Newly diagnosed glioblastoma is now commonly treated with surgery, if feasible, or biopsy,
followed by radiation plus concomitant and adjuvant temozolomide. The treatment of …

Current methods used for measuring amino acid side-chain reactivity lack the throughput
needed to screen large chemical libraries for interactions across the proteome. Here we …

Biomarkers are naturally-occurring characteristics by which a particular pathological process
or disease can be identified or monitored. They can reflect past environmental exposures …

PURPOSE The VIT-0910 trial was conducted to evaluate efficacy and safety of the
vincristine-irinotecan combination with and without temozolomide (VIT and VI, respectively) …

Abstract Purpose: Pharmacologic ascorbate (P-AscH−) is hypothesized to be an iron (Fe)-
dependent tumor-specific adjuvant to chemoradiation in treating glioblastoma (GBM). This …

Prostate cancer is a major cause of cancer‐related deaths among men worldwide. In
addition to genomic alterations, epigenetic alterations accumulated in prostate cancer have …

Cyclophosphamide–dacarbazine–vincristine regimen is recommended for the treatment of
malignant pheochromocytoma and paraganglioma (MPP); however, dacarbazine is the only …

O 6-Alkylguanine-DNA alkyltransferase (AGT) is a widely distributed, unique DNA repair
protein that acts as a single agent to directly remove alkyl groups located on the O 6-position …

Human pituitary adenomas are the most common intracranial neoplasms. Approximately 5%
of them are familial adenomas. Patients with familial tumors carry germline mutations in …