Progesterone is commonly considered as a female reproductive hormone and is well-known
for its role in pregnancy. It is less well appreciated that progesterone and its metabolite …

Estrogen is a pivotal enzyme for survival and health in both genders, though their quantum,
tropism, tissue-specific distribution, and receptor affinity varies with different phases of life …

Human health is beset with a legion of ailments, which is exacerbated by lifestyle errors. Out
of the numerous enzymes in human body, aromatase, a cytochrome P450 enzyme is …

The growth modulating effects of the ovarian steroid hormones 17β-estradiol (E2) and
progesterone (PRG) on endocrine-responsive target tissues are well established. In …

Steroids consist of an essentially lipophilic (or hydrophobic, non-polar)
cyclopentanoperhydrophenanthrene nucleus modified on the periphery of the nucleus or on …

Neuroactive steroids can rapidly regulate multiple physiological functions in the central and
peripheral nervous systems. The aims of the present study were to determine whether …

Vertebrate reproduction involves complex steroid hormone interplay and inter-conversion. A
critical element in maintaining sex steroid levels is the enzyme aromatase (cytochrome P450 …

Aromatase inhibitors (AI) are considered as a first line therapy for ER+ PR+ breast cancers.
However, many patients acquire resistance to AI. In this study, we determined the response …

Recent data suggest a novel role of progesterone in breast cancer etiology involving the
progesterone metabolites 3α-dihydroprogesterone (3αHP), 5α-dihydroprogesterone (5αP) …

It is well documented that breast tissue, both normal and cancerous, contains all the
enzymatic systems necessary for the bioformation and metabolic transformation of …