Radiotherapy plays a central part in curing cancer. For decades, most research on
improving treatment outcomes has focused on modulating radiation-induced biological …

The TGFβ signaling pathway has pleiotropic functions regulating cell growth, differentiation,
apoptosis, motility and invasion, extracellular matrix production, angiogenesis, and immune …

Antibodies targeting immune checkpoints are emerging as potent and viable cancer
therapies, but not all patients respond to these as single agents. Concurrently targeting …

Genetic alterations affecting transforming growth factor–β (TGF-β) signaling are
exceptionally common in diseases and cancers of the gastrointestinal system. As a regulator …

Transforming growth factor-β (TGF-β) regulates cell growth and differentiation, apoptosis,
cell motility, extracellular matrix production, angiogenesis, and cellular immunity. It has a …

Simple Summary Stroma modifications observed in solid cancer are now recognized as
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …

Background N6-methyladenosine (m6A) modification holds an important position in
tumorigenesis and metastasis because it can change gene expression and even function in …

Pancreatic cancer is one of the most lethal malignancies. Significant progresses have been
made in understanding of pancreatic cancer pathogenesis, including appreciation of …

Although anti–PD-1 therapy has improved clinical outcomes for select patients with
advanced cancer, many patients exhibit either primary or adaptive resistance to checkpoint …

Patients with pancreatic cancer normally present with advanced disease that is lethal and
notoriously difficult to treat. Survival has not improved dramatically despite routine use of …